Detailed information of TA system TA155608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3162638..3163299
• Replicon: chromosome
• Accession: NZ_CP052851
• Organism: Bordetella parapertussis strain J677

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB56_RS14905
• Protein ID: WP_003812073.1
• Coordinates: 3162874..3163299 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB56_RS14900
• Protein ID: WP_003812071.1
• Coordinates: 3162638..3162877 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB56_RS14865	3157673..3158476	-	804	WP_003812055.1	bacteriocin family protein	-
FYB56_RS14870	3158473..3159519	-	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB56_RS14875	3159597..3160157	-	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB56_RS14880	3160154..3160387	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB56_RS14885	3160468..3160980	-	513	WP_003812062.1	redoxin domain-containing protein	-
FYB56_RS14890	3161039..3161584	-	546	WP_010928020.1	peroxidase-related enzyme	-
FYB56_RS14895	3161722..3162564	+	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB56_RS14900	3162638..3162877	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB56_RS14905	3162874..3163299	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB56_RS14910	3163409..3163873	+	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB56_RS14915	3163971..3165476	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB56_RS14920	3165975..3166487	+	513	WP_010928017.1	hypothetical protein	-
FYB56_RS14925	3166508..3167485	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T155608 WP_003812073.1 NZ_CP052851:3162874-3163299 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T155608 NZ_CP068808:4498308-4498565 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGCCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT155608 WP_003812071.1 NZ_CP052851:3162638-3162877 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT155608 NZ_CP068808:4498577-4499128 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCGACCTTCAAAGGAGAAATGGATTCACCGCTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: Q7WAH5