Detailed information of TA system TA155602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2574067..2574598
• Replicon: chromosome
• Accession: NZ_CP052850
• Organism: Bordetella parapertussis strain J778

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYB61_RS12085
• Protein ID: WP_003812626.1
• Coordinates: 2574067..2574333 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYB61_RS12090
• Protein ID: WP_003816743.1
• Coordinates: 2574320..2574598 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB61_RS12060	2569194..2569466	+	273	WP_003812615.1	hypothetical protein	-
FYB61_RS12065	2569505..2570215	-	711	WP_003812617.1	aquaporin Z	-
FYB61_RS12070	2570326..2570958	-	633	WP_003812619.1	PAS domain-containing protein	-
FYB61_RS12075	2571355..2572233	+	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB61_RS12080	2572295..2573836	+	1542	WP_010928296.1	M81 family metallopeptidase	-
FYB61_RS12085	2574067..2574333	+	267	WP_003812626.1	BrnT family toxin	Toxin
FYB61_RS12090	2574320..2574598	+	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYB61_RS12100	2574892..2575548	-	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYB61_RS12105	2575563..2577230	-	1668	WP_010928294.1	TRAP transporter large permease subunit	-
FYB61_RS12110	2577233..2577862	-	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYB61_RS12115	2578074..2579168	-	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T155602 WP_003812626.1 NZ_CP052850:2574067-2574333 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T155602 NZ_CP068808:3164835-3165329 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT155602 WP_003816743.1 NZ_CP052850:2574320-2574598 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT155602 NZ_CP068808:3164545-3164838 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02