Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2439827..2440421 Replicon chromosome
Accession NZ_CP052850
Organism Bordetella parapertussis strain J778

Toxin (Protein)


Gene name hicA Uniprot ID K0M8J0
Locus tag FYB61_RS11450 Protein ID WP_010928352.1
Coordinates 2439827..2440009 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID K0MFV7
Locus tag FYB61_RS11455 Protein ID WP_010928351.1
Coordinates 2440032..2440421 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB61_RS11430 2434830..2435570 + 741 WP_003809659.1 carbonic anhydrase -
FYB61_RS11435 2435582..2436937 - 1356 WP_003809657.1 cytochrome c -
FYB61_RS11440 2436948..2438717 - 1770 WP_010928353.1 GMC family oxidoreductase -
FYB61_RS11445 2438721..2439419 - 699 WP_003809653.1 gluconate 2-dehydrogenase subunit 3 family protein -
FYB61_RS11450 2439827..2440009 + 183 WP_010928352.1 type II toxin-antitoxin system HicA family toxin Toxin
FYB61_RS11455 2440032..2440421 + 390 WP_010928351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYB61_RS11465 2440687..2441463 - 777 WP_033448479.1 phosphate ABC transporter ATP-binding protein PstB -
FYB61_RS11470 2441508..2442365 - 858 WP_003809638.1 phosphate ABC transporter permease PstA -
FYB61_RS11475 2442387..2443403 - 1017 WP_010928350.1 phosphate ABC transporter permease subunit PstC -
FYB61_RS11480 2443538..2444578 - 1041 WP_003809635.1 phosphate ABC transporter substrate-binding protein PstS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-122)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6750.76 Da        Isoelectric Point: 11.4018

>T155601 WP_010928352.1 NZ_CP052850:2439827-2440009 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Download         Length: 183 bp

>T155601 NZ_CP068808:2990014-2990121 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14270.92 Da        Isoelectric Point: 4.3014

>AT155601 WP_010928351.1 NZ_CP052850:2440032-2440421 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Download         Length: 390 bp

>AT155601 NZ_CP068808:c2989964-2989901 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0M8J0

Antitoxin

Source ID Structure
AlphaFold DB K0MFV7

References