Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1725954..1726567 Replicon chromosome
Accession NZ_CP052850
Organism Bordetella parapertussis strain J778

Toxin (Protein)


Gene name higB Uniprot ID K0MEM3
Locus tag FYB61_RS08060 Protein ID WP_003811545.1
Coordinates 1726256..1726567 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FYB61_RS08055 Protein ID WP_003811547.1
Coordinates 1725954..1726253 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB61_RS08045 1722545..1723219 - 675 WP_010928712.1 response regulator transcription factor -
FYB61_RS08050 1723349..1725940 + 2592 WP_065956700.1 autotransporter domain-containing protein -
FYB61_RS08055 1725954..1726253 - 300 WP_003811547.1 helix-turn-helix domain-containing protein Antitoxin
FYB61_RS08060 1726256..1726567 - 312 WP_003811545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYB61_RS08065 1726681..1727304 - 624 WP_003811542.1 glutathione S-transferase family protein -
FYB61_RS08070 1727423..1728376 - 954 WP_041937234.1 LysR family transcriptional regulator -
FYB61_RS08075 1728493..1729455 + 963 WP_041937418.1 tripartite tricarboxylate transporter substrate binding protein -
FYB61_RS08080 1729470..1730864 + 1395 WP_003811536.1 arylsulfatase -
FYB61_RS08085 1730861..1731415 + 555 Protein_1601 LamB/YcsF family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11810.72 Da        Isoelectric Point: 8.8245

>T155600 WP_003811545.1 NZ_CP052850:c1726567-1726256 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Download         Length: 312 bp

>T155600 NZ_CP068808:2989479-2989586 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10946.70 Da        Isoelectric Point: 11.2467

>AT155600 WP_003811547.1 NZ_CP052850:c1726253-1725954 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT155600 NZ_CP068808:c2989432-2989366 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MEM3

Antitoxin

Source ID Structure

References