Detailed information of TA system TA155392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3383919..3385555
• Replicon: chromosome
• Accession: NZ_CP051869
• Organism: Acinetobacter baumannii strain Ab-D10a-a

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A858S2C4
• Locus tag: HIN87_RS16500
• Protein ID: WP_031379782.1
• Coordinates: 3384224..3385555 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HIN87_RS16495
• Protein ID: WP_001101310.1
• Coordinates: 3383919..3384227 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HIN87_RS16465	3378930..3379766	+	837	WP_032000325.1	SDR family NAD(P)-dependent oxidoreductase	-
HIN87_RS16470	3379850..3380632	-	783	WP_032000324.1	HNH endonuclease	-
HIN87_RS16475	3380838..3381356	-	519	WP_032000323.1	GNAT family N-acetyltransferase	-
HIN87_RS16480	3381450..3381866	-	417	WP_032000322.1	hypothetical protein	-
HIN87_RS16485	3381929..3382555	-	627	WP_032000320.1	hypothetical protein	-
HIN87_RS16490	3382628..3383194	-	567	WP_032000319.1	TetR/AcrR family transcriptional regulator	-
HIN87_RS16495	3383919..3384227	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
HIN87_RS16500	3384224..3385555	-	1332	WP_031379782.1	type II toxin-antitoxin system HipA family toxin	Toxin
HIN87_RS16505	3385851..3386291	+	441	WP_057048971.1	HD domain-containing protein	-
HIN87_RS16510	3386326..3386970	-	645	WP_032000318.1	hypothetical protein	-
HIN87_RS16515	3386982..3387953	-	972	WP_111818113.1	5'/3'-nucleotidase SurE	-
HIN87_RS16520	3388080..3389243	-	1164	WP_032000316.1	hypothetical protein	-
HIN87_RS16525	3389236..3390474	-	1239	WP_111818114.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51202.34 Da
• Isoelectric Point: 4.9820

>T155392 WP_031379782.1 NZ_CP051869:c3385555-3384224 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T155392 NZ_CP068800:3056958-3057065 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT155392 WP_001101310.1 NZ_CP051869:c3384227-3383919 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT155392 NZ_CP068800:c3056908-3056845 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A858S2C4