Detailed information of TA system TA155351

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-ohsC/SymE(toxin)
• Location: 4564057..4564469
• Replicon: chromosome
• Accession: NZ_CP051849
• Organism: Escherichia coli strain SCU-101

Toxin (Protein)

• Gene name: symE
• Uniprot ID: Q8FA88
• Locus tag: HHJ20_RS22185
• Protein ID: WP_000132630.1
• Coordinates: 4564128..4564469 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4564057..4564133 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ20_RS22175 (4560669)	4560669..4562138	+	1470	WP_001315223.1	type I restriction-modification system subunit M	-
HHJ20_RS22180 (4562138)	4562138..4563907	+	1770	WP_000110076.1	restriction endonuclease subunit S	-
- (4564057)	4564057..4564133	-	77	NuclAT_6	-	Antitoxin
- (4564057)	4564057..4564133	-	77	NuclAT_6	-	Antitoxin
- (4564057)	4564057..4564133	-	77	NuclAT_6	-	Antitoxin
- (4564057)	4564057..4564133	-	77	NuclAT_6	-	Antitoxin
- (4564057)	4564057..4564133	-	77	NuclAT_7	-	Antitoxin
- (4564057)	4564057..4564133	-	77	NuclAT_7	-	Antitoxin
- (4564057)	4564057..4564133	-	77	NuclAT_7	-	Antitoxin
- (4564057)	4564057..4564133	-	77	NuclAT_7	-	Antitoxin
HHJ20_RS22185 (4564128)	4564128..4564469	+	342	WP_000132630.1	endoribonuclease SymE	Toxin
HHJ20_RS26290 (4564516)	4564516..4565679	-	1164	WP_072202028.1	DUF1524 domain-containing protein	-
HHJ20_RS26295 (4565727)	4565727..4566609	-	883	Protein_4383	DUF262 domain-containing protein	-
HHJ20_RS22200 (4567015)	4567015..4567935	-	921	WP_000181195.1	Rpn family recombination-promoting nuclease/putative transposase	-
HHJ20_RS22205 (4568120)	4568120..4569400	+	1281	WP_001304526.1	DUF445 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12294.13 Da
• Isoelectric Point: 8.4982

>T155351 WP_000132630.1 NZ_CP051849:4564128-4564469 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T155351 NZ_CP068798:c5052435-5051518 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCACTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 77 bp

>AT155351 NZ_CP051849:c4564133-4564057 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A0E0Y5T0

Antitoxin