Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3261128..3261929 Replicon chromosome
Accession NZ_CP051849
Organism Escherichia coli strain SCU-101

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag HHJ20_RS16020 Protein ID WP_000854739.1
Coordinates 3261128..3261508 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HHJ20_RS16025 Protein ID WP_001285482.1
Coordinates 3261555..3261929 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ20_RS15985 (3256719) 3256719..3257273 - 555 WP_001001909.1 molecular chaperone YcdY -
HHJ20_RS15990 (3257297) 3257297..3258034 - 738 WP_000283664.1 zinc-binding phosphatase -
HHJ20_RS15995 (3258089) 3258089..3259027 - 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
HHJ20_RS16005 (3259498) 3259498..3260341 - 844 Protein_3169 DUF4942 domain-containing protein -
HHJ20_RS16010 (3260426) 3260426..3260623 - 198 WP_000772027.1 DUF957 domain-containing protein -
HHJ20_RS16015 (3260643) 3260643..3261131 - 489 WP_001054232.1 DUF5983 family protein -
HHJ20_RS16020 (3261128) 3261128..3261508 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
HHJ20_RS16025 (3261555) 3261555..3261929 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ20_RS16030 (3261979) 3261979..3262623 - 645 WP_000086763.1 hypothetical protein -
HHJ20_RS16035 (3262642) 3262642..3262863 - 222 WP_000692315.1 DUF987 domain-containing protein -
HHJ20_RS16040 (3262926) 3262926..3263402 - 477 WP_001186170.1 RadC family protein -
HHJ20_RS16045 (3263418) 3263418..3263891 - 474 WP_001313575.1 antirestriction protein -
HHJ20_RS16050 (3264154) 3264154..3264975 - 822 WP_001234710.1 DUF932 domain-containing protein -
HHJ20_RS26225 (3265154) 3265154..3265243 - 90 WP_230607454.1 DUF905 family protein -
HHJ20_RS16060 (3265386) 3265386..3265841 - 456 WP_000581502.1 IrmA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T155345 WP_000854739.1 NZ_CP051849:c3261508-3261128 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T155345 NZ_CP068798:1971672-1971774 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT155345 WP_001285482.1 NZ_CP051849:c3261929-3261555 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT155345 NZ_CP068798:c1971781-1971636 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References