Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3801085..3801917 Replicon chromosome
Accession NZ_CP051753
Organism Escherichia coli strain SCU-102

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HHJ21_RS17920 Protein ID WP_001680708.1
Coordinates 3801543..3801917 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HHJ21_RS17915 Protein ID WP_001680709.1
Coordinates 3801085..3801453 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ21_RS17875 3796809..3797489 + 681 WP_001282921.1 WYL domain-containing protein -
HHJ21_RS17880 3797637..3798314 + 678 WP_001097302.1 hypothetical protein -
HHJ21_RS17885 3798320..3798553 + 234 WP_001278293.1 DUF905 family protein -
HHJ21_RS17890 3798643..3799461 + 819 WP_001175165.1 DUF945 domain-containing protein -
HHJ21_RS17895 3799727..3800206 + 480 WP_000706978.1 antirestriction protein -
HHJ21_RS17900 3800221..3800697 + 477 WP_140441646.1 RadC family protein -
HHJ21_RS17905 3800784..3800876 + 93 WP_000692337.1 DUF987 family protein -
HHJ21_RS17910 3800880..3801005 + 126 Protein_3489 DUF987 family protein -
HHJ21_RS17915 3801085..3801453 + 369 WP_001680709.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ21_RS17920 3801543..3801917 + 375 WP_001680708.1 TA system toxin CbtA family protein Toxin
HHJ21_RS17925 3801914..3802402 + 489 WP_001680706.1 hypothetical protein -
HHJ21_RS17930 3802414..3802611 + 198 WP_000839281.1 DUF957 domain-containing protein -
HHJ21_RS17935 3802708..3803277 + 570 WP_001290247.1 DUF4942 domain-containing protein -
HHJ21_RS17940 3803620..3803790 + 171 Protein_3495 IS110 family transposase -
HHJ21_RS17945 3804601..3805584 + 984 WP_001355482.1 KpsF/GutQ family sugar-phosphate isomerase -
HHJ21_RS17950 3805656..3806804 + 1149 WP_097410338.1 capsule biosynthesis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14017.06 Da        Isoelectric Point: 8.2905

>T155298 WP_001680708.1 NZ_CP051753:3801543-3801917 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T155298 NZ_CP068795:2742027-2742134 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13541.33 Da        Isoelectric Point: 6.8501

>AT155298 WP_001680709.1 NZ_CP051753:3801085-3801453 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT155298 NZ_CP068795:c2741980-2741914 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References