Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4571693..4572525 Replicon chromosome
Accession NZ_CP051744
Organism Escherichia coli strain SCU-484

Toxin (Protein)


Gene name yeeV Uniprot ID A0A426P9T8
Locus tag HHJ53_RS21870 Protein ID WP_001555674.1
Coordinates 4572151..4572525 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A085P7I7
Locus tag HHJ53_RS21865 Protein ID WP_001327592.1
Coordinates 4571693..4572061 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ53_RS21825 4567278..4567958 + 681 WP_001555671.1 WYL domain-containing protein -
HHJ53_RS21830 4568106..4568783 + 678 WP_001555672.1 hypothetical protein -
HHJ53_RS21835 4568789..4569022 + 234 WP_001278282.1 DUF905 family protein -
HHJ53_RS21840 4569112..4569930 + 819 WP_001555673.1 DUF945 domain-containing protein -
HHJ53_RS21850 4570269..4570748 + 480 WP_000706981.1 antirestriction protein -
HHJ53_RS21855 4570764..4571240 + 477 WP_001186727.1 RadC family protein -
HHJ53_RS21860 4571309..4571530 + 222 WP_000692323.1 DUF987 domain-containing protein -
HHJ53_RS21865 4571693..4572061 + 369 WP_001327592.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ53_RS21870 4572151..4572525 + 375 WP_001555674.1 TA system toxin CbtA family protein Toxin
HHJ53_RS21875 4572522..4573013 + 492 WP_001555675.1 hypothetical protein -
HHJ53_RS21880 4573033..4573230 + 198 WP_000445282.1 DUF957 domain-containing protein -
HHJ53_RS21885 4573315..4574156 + 842 Protein_4280 DUF4942 domain-containing protein -
HHJ53_RS21890 4574904..4576442 + 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4560540..4584255 23715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14205.16 Da        Isoelectric Point: 8.2918

>T155243 WP_001555674.1 NZ_CP051744:4572151-4572525 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAK

Download         Length: 375 bp

>T155243 NZ_CP068708:809645-810412 [Streptococcus suis]
ATGAGACTGGAAGAATTTAGTGAGGCTGAGTTTCAGAAGGCCTTGCAGCGAACCATTCGGGCCTTAACCCGAGGAAAGAC
GATTCCAGATCAACCGAAAGCTATTTTGCTTGGTGGACAAAGCGGAGCAGGTAAGACGACTATTCATCGTATCAAGCAAA
AGGAATTTCAAGGTAATATCATTATTATCGATGGTGACAGCTACCGTTCTCAGCATCCCAATTACTTAGCCCTGCAAGAA
AAGTATGGCAAGGATAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAACAGTTGGTTGATGAACTCAGTAC
GCAAGGCTACCATTTGCTGATTGAGGGAACCTTGCGAACTACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGTACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAG
CTTTATGCCATCGATCCGACTCAGGCTAGAGCAACACCAAAAGAACACCACGATGGGATTGTTGAGAACTTGGTTGATAA
CTTGAGGGAGTTAGAAAGTGAAAATCTCTTTGACCAGATTCAAATTTATCAAAGAGATAGAACTTGTATCTATGATTCTG
AAACTGCTGAAGGTTCCGCAGCAGAAGTGCTACAAGAATGCCTATTTGGAAAATGGAGCAAGGTAGAGGAGGAGATGGTG
AAGGAGAGTGAACTCCTACTTAAGGAATTACTTGAGAAAAATAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13901.65 Da        Isoelectric Point: 6.3165

>AT155243 WP_001327592.1 NZ_CP051744:4571693-4572061 [Escherichia coli]
VSDTHHETNYPDDYNNRPWWGLPCTITPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT155243 NZ_CP068708:809169-809645 [Streptococcus suis]
ATGATCGGAGACAATATAAAATCACTACGCCGAACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGCTACGAAAATGGTACCAGCACTGTTTCAACTGAACTCATCGACCGTATTTGTCAGAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTCGAAGATTACCATCTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCAAAGCTTTATAGATACCAGGATAGTCAAGATATTGTTTTTGATGATGA
ATCTAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATCAATACGAAAATTTACCTTGTCGCTACTTTCGATG
AAATAGAGCGTTACAATGGCTATTTAGATGGTATAGAGCGGATGTTAGACATGGTGCATCATCGGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A426P9T8

Antitoxin

Source ID Structure
AlphaFold DB A0A085P7I7

References