Detailed information of TA system TA155240

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4196201..4196459
• Replicon: chromosome
• Accession: NZ_CP051744
• Organism: Escherichia coli strain SCU-484

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HHJ53_RS20050
• Protein ID: WP_000809168.1
• Coordinates: 4196307..4196459 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4196201..4196258 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ53_RS20035	4192030..4193289	-	1260	WP_000494929.1	hypothetical protein	-
HHJ53_RS20040	4193418..4194911	-	1494	WP_001350365.1	sulfatase-like hydrolase/transferase	-
HHJ53_RS20045	4194931..4195692	-	762	WP_001274832.1	hypothetical protein	-
-	4196201..4196258	-	58	-	-	Antitoxin
HHJ53_RS20050	4196307..4196459	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HHJ53_RS20055	4196564..4197694	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ53_RS20060	4197783..4199699	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ53_RS20065	4200071..4200475	+	405	WP_000843692.1	DUF2541 family protein	-
HHJ53_RS20070	4200501..4201214	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T155240 WP_000809168.1 NZ_CP051744:4196307-4196459 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T155240 NZ_CP068707:c312503-312033 [Escherichia coli]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT155240 NZ_CP051744:c4196258-4196201 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin