Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3024480..3025275 Replicon chromosome
Accession NZ_CP051744
Organism Escherichia coli strain SCU-484

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag HHJ53_RS14520 Protein ID WP_001094434.1
Coordinates 3024480..3024854 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag HHJ53_RS14525 Protein ID WP_001285482.1
Coordinates 3024901..3025275 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ53_RS14485 3020069..3020623 - 555 WP_001001913.1 molecular chaperone YcdY -
HHJ53_RS14490 3020647..3021384 - 738 WP_000283656.1 zinc-binding phosphatase -
HHJ53_RS14495 3021439..3022377 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
HHJ53_RS14505 3022848..3023690 - 843 WP_001280460.1 DUF4942 domain-containing protein -
HHJ53_RS14510 3023783..3023980 - 198 WP_000839257.1 DUF957 domain-containing protein -
HHJ53_RS14515 3023992..3024483 - 492 WP_000976859.1 hypothetical protein -
HHJ53_RS14520 3024480..3024854 - 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
HHJ53_RS14525 3024901..3025275 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HHJ53_RS14530 3025325..3025969 - 645 WP_000086762.1 hypothetical protein -
HHJ53_RS14535 3025988..3026209 - 222 WP_000692315.1 DUF987 domain-containing protein -
HHJ53_RS14540 3026272..3026748 - 477 WP_001313574.1 RadC family protein -
HHJ53_RS14545 3026764..3027237 - 474 WP_001313575.1 antirestriction protein -
HHJ53_RS14555 3027574..3028395 - 822 WP_001234582.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T155236 WP_001094434.1 NZ_CP051744:c3024854-3024480 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T155236 NZ_CP068707:c104782-104498 [Escherichia coli]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT155236 WP_001285482.1 NZ_CP051744:c3025275-3024901 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT155236 NZ_CP068707:c105020-104772 [Escherichia coli]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1RDD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References