Detailed information of TA system TA155199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2555885..2557473
• Replicon: chromosome
• Accession: NZ_CP051738
• Organism: Escherichia coli strain SCU-105

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2K3TSW7
• Locus tag: HHJ23_RS12455
• Protein ID: WP_001544563.1
• Coordinates: 2556151..2557473 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: HHJ23_RS12450
• Protein ID: WP_001296726.1
• Coordinates: 2555885..2556151 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ23_RS12450	2555885..2556151	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HHJ23_RS12455	2556151..2557473	+	1323	WP_001544563.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
HHJ23_RS12460	2557870..2558769	-	900	WP_001057776.1	LysR family transcriptional regulator	-
HHJ23_RS12465	2558909..2559217	+	309	WP_001221046.1	hypothetical protein	-
HHJ23_RS12470	2559226..2559915	+	690	WP_001544561.1	type 1 glutamine amidotransferase domain-containing protein	-
HHJ23_RS12475	2559989..2560936	+	948	WP_000854796.1	aldo/keto reductase	-
HHJ23_RS12480	2561039..2561194	+	156	WP_001322415.1	hypothetical protein	-
HHJ23_RS12485	2561154..2561573	+	420	WP_001544559.1	amidohydrolase family protein	-
HHJ23_RS12490	2561524..2561715	+	192	WP_001469139.1	amidohydrolase family protein	-
HHJ23_RS12495	2561866..2562438	+	573	WP_000789913.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49416.09 Da
• Isoelectric Point: 8.8753

>T155199 WP_001544563.1 NZ_CP051738:2556151-2557473 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHRRLSREYGIK

Nucleotide

• Length: 1323 bp

>T155199 NZ_CP068696:1310842-1311255 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT155199 WP_001296726.1 NZ_CP051738:2555885-2556151 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT155199 NZ_CP068696:1310595-1310861 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A2K3TSW7