Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 77175..77710 Replicon plasmid pSCU-111-1
Accession NZ_CP051728
Organism Escherichia coli strain SCU-111

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HHJ28_RS23215 Protein ID WP_169062089.1
Coordinates 77423..77710 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HHJ28_RS23210 Protein ID WP_169062088.1
Coordinates 77175..77426 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ28_RS23190 72352..72729 - 378 Protein_81 IS110 family transposase -
HHJ28_RS23195 72761..74191 - 1431 Protein_82 IS66 family transposase -
HHJ28_RS23200 74194..74781 + 588 Protein_83 tyrosine-type recombinase/integrase -
HHJ28_RS23205 75508..75978 - 471 WP_169062142.1 helix-turn-helix transcriptional regulator -
HHJ28_RS23210 77175..77426 + 252 WP_169062088.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HHJ28_RS23215 77423..77710 + 288 WP_169062089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHJ28_RS23220 78259..78336 + 78 Protein_87 IS66 family insertion sequence element accessory protein TnpB -
HHJ28_RS23225 78336..78474 + 139 Protein_88 IS66 family insertion sequence element accessory protein TnpB -
HHJ28_RS23230 78569..79107 - 539 Protein_89 IS21 family transposase -
HHJ28_RS23235 79201..80367 + 1167 WP_169062090.1 plasmid-partitioning protein SopA -
HHJ28_RS23240 80367..81338 + 972 WP_169062091.1 ParB/RepB/Spo0J family plasmid partition protein -
HHJ28_RS23245 82160..82633 - 474 WP_169062092.1 DUF2919 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - acrB / pet / etpB / etpB / cdtC / cdtB / cdtA / etpA / etpB 1..189717 189717
- inside IScluster/Tn - pet 63421..81991 18570


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11143.07 Da        Isoelectric Point: 10.1343

>T155108 WP_169062089.1 NZ_CP051728:77423-77710 [Escherichia coli]
MTYTVKFRDDALKEWHKLDKTIQQQFAKKLKKCCENPHIPSAKLRGIRDCYEIKLRASGFRLVYQVIDAELIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T155108 NZ_CP068650:c52138-51884 [Vibrio parahaemolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATGGTCTTAAAGCTGTTTTAGACGGTGTAGTTAATGACGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAAGATGCCGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACAGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACATCTAAATCGCTCGATTGCACAGTACCGTGCTGGTAAAACAACAGCACGAGAG
TTAATCGATGAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9193.44 Da        Isoelectric Point: 4.3396

>AT155108 WP_169062088.1 NZ_CP051728:77175-77426 [Escherichia coli]
MPNIILTDTSASVSELKKNPMATVSAGDGYPVAILNRNHPAFYCVPADLYEKMLDALDDQELVKLVAERSNQKLHDVDLD
SYL

Download         Length: 252 bp

>AT155108 NZ_CP068650:c51891-51622 [Vibrio parahaemolyticus]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAACAAACTCATCAATGATATTAAGCGTTCCTCATTTGAGGGCATCGGTAAACCAGAGCCATTAA
AAGAGAACTTATCTGGCTTTTGGTCTCGCCGTATTGATGACACTAATAGGCTTGTTTACGCAGTCGATGACCAAGCTATA
ACGATAATTTCGTGTCGTTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References