Detailed information of TA system TA155100

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3946870..3947128
• Replicon: chromosome
• Accession: NZ_CP051727
• Organism: Escherichia coli strain SCU-111

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HHJ28_RS18800
• Protein ID: WP_000809168.1
• Coordinates: 3946976..3947128 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3946870..3946927 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ28_RS18785	3942699..3943958	-	1260	WP_000494928.1	hypothetical protein	-
HHJ28_RS18790	3944087..3945580	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
HHJ28_RS18795	3945600..3946361	-	762	WP_001274832.1	hypothetical protein	-
-	3946870..3946927	-	58	-	-	Antitoxin
HHJ28_RS18800	3946976..3947128	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HHJ28_RS18805	3947233..3948363	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ28_RS18810	3948452..3950368	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ28_RS18815	3950740..3951144	+	405	WP_001765391.1	DUF2541 family protein	-
HHJ28_RS18820	3951170..3951883	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T155100 WP_000809168.1 NZ_CP051727:3946976-3947128 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T155100 NZ_CP068641:c1446183-1445884 [Vibrio parahaemolyticus]
ATGCAAAAGAACAAATACAAGCTAAGTAACTTAGCGCAATCTCACTTGCGCAAAGTAAAAGACTACACTGTTGAAAACTT
TTCTGAATTACAGTGGCGTAACTACAAAGATACTCTGCTATCAGGGTTTCAGATGCTAGCTGATAATCCAGACTTAGGAA
GAAGTTGTGACGAGATATACCCAAATGGCTTTTATTTCCCGATTGGAAAACACACAGCTTATTTCATCAAAGAAGATGAC
TTTATCTTAGTCGTTGCTGTCTTAGGTCAATCACAGCTACCCCAGAATCATCTGAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT155100 NZ_CP051727:c3946927-3946870 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin