Detailed information of TA system TA155063

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4169576..4169834
• Replicon: chromosome
• Accession: NZ_CP051725
• Organism: Escherichia coli strain SCU-112

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: HHJ29_RS19900
• Protein ID: WP_000809168.1
• Coordinates: 4169682..4169834 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4169576..4169633 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHJ29_RS19885	4165405..4166664	-	1260	WP_000494928.1	hypothetical protein	-
HHJ29_RS19890	4166793..4168286	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
HHJ29_RS19895	4168306..4169067	-	762	WP_001274832.1	hypothetical protein	-
-	4169576..4169633	-	58	-	-	Antitoxin
HHJ29_RS19900	4169682..4169834	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
HHJ29_RS19905	4169939..4171069	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHJ29_RS19910	4171158..4173074	-	1917	WP_000516135.1	molecular chaperone DnaK	-
HHJ29_RS19915	4173446..4173850	+	405	WP_000843687.1	DUF2541 family protein	-
HHJ29_RS19920	4173876..4174589	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T155063 WP_000809168.1 NZ_CP051725:4169682-4169834 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T155063 NZ_CP068618:738707-739192 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT155063 NZ_CP051725:c4169633-4169576 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin