Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3102814..3103645 Replicon chromosome
Accession NZ_CP051688
Organism Escherichia coli strain SCU-387

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HHJ48_RS15245 Protein ID WP_000854814.1
Coordinates 3103271..3103645 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag HHJ48_RS15240 Protein ID WP_001285586.1
Coordinates 3102814..3103182 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ48_RS15205 3097871..3098941 + 1071 WP_000102631.1 patatin-like phospholipase family protein -
HHJ48_RS15210 3099077..3099754 + 678 WP_001362823.1 hypothetical protein -
HHJ48_RS15215 3099770..3100180 + 411 WP_000846704.1 hypothetical protein -
HHJ48_RS15220 3100401..3101222 + 822 WP_001234571.1 DUF945 domain-containing protein -
HHJ48_RS15225 3101485..3101958 + 474 WP_001537423.1 antirestriction protein -
HHJ48_RS15230 3101974..3102450 + 477 WP_021531870.1 RadC family protein -
HHJ48_RS15235 3102519..3102740 + 222 WP_000692323.1 DUF987 domain-containing protein -
HHJ48_RS15240 3102814..3103182 + 369 WP_001285586.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HHJ48_RS15245 3103271..3103645 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HHJ48_RS15250 3103642..3103836 + 195 WP_000988601.1 hypothetical protein -
HHJ48_RS15255 3103849..3103962 + 114 WP_001161660.1 DUF957 domain-containing protein -
HHJ48_RS15260 3104251..3104397 - 147 Protein_2983 transposase domain-containing protein -
HHJ48_RS15265 3104451..3104633 + 183 WP_033548241.1 ethanolamine utilization protein -
HHJ48_RS15270 3104733..3105062 - 330 WP_000450409.1 DUF496 family protein -
HHJ48_RS15275 3105234..3106292 - 1059 WP_001200890.1 FUSC family protein -
HHJ48_RS15280 3106490..3106963 - 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
HHJ48_RS15285 3107082..3108248 - 1167 WP_033548239.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T154775 WP_000854814.1 NZ_CP051688:3103271-3103645 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T154775 NZ_CP068279:c2458434-2458327 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT154775 WP_001285586.1 NZ_CP051688:3102814-3103182 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT154775 NZ_CP068279:2458482-2458548 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References