Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 720615..720873 Replicon chromosome
Accession NZ_CP051688
Organism Escherichia coli strain SCU-387

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag HHJ48_RS03435 Protein ID WP_000809168.1
Coordinates 720615..720767 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 720816..720873 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHJ48_RS03415 715861..716574 - 714 WP_001102391.1 acidic protein MsyB -
HHJ48_RS03420 716600..717004 - 405 WP_000843687.1 DUF2541 family protein -
HHJ48_RS03425 717375..719291 + 1917 WP_000516135.1 molecular chaperone DnaK -
HHJ48_RS03430 719380..720510 + 1131 WP_001118464.1 molecular chaperone DnaJ -
HHJ48_RS03435 720615..720767 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 720816..720873 + 58 - - Antitoxin
HHJ48_RS03440 721382..722143 + 762 WP_001274832.1 hypothetical protein -
HHJ48_RS03445 722163..723656 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
HHJ48_RS03450 723785..725044 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T154759 WP_000809168.1 NZ_CP051688:c720767-720615 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T154759 NZ_CP068249:2945976-2946119 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAAAAGACAATAAAAAATAA

Antitoxin


Download         Length: 58 bp

>AT154759 NZ_CP051688:720816-720873 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References