Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4040922..4041582 Replicon chromosome
Accession NZ_CP051652
Organism Pectobacterium carotovorum strain WPP14

Toxin (Protein)


Gene name cptA Uniprot ID A0A419ATT9
Locus tag HER17_RS17920 Protein ID WP_029368427.1
Coordinates 4040922..4041335 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag HER17_RS17925 Protein ID WP_005971623.1
Coordinates 4041316..4041582 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HER17_RS17895 4036720..4038048 + 1329 WP_010301826.1 MHS family MFS transporter -
HER17_RS17900 4038256..4038642 + 387 WP_010301824.1 thioesterase family protein -
HER17_RS17905 4038982..4039500 + 519 WP_010301821.1 flavodoxin FldB -
HER17_RS17910 4039529..4039852 + 324 WP_010301820.1 hypothetical protein -
HER17_RS17915 4039918..4040853 - 936 WP_010301818.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
HER17_RS17920 4040922..4041335 - 414 WP_029368427.1 protein YgfX Toxin
HER17_RS17925 4041316..4041582 - 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
HER17_RS17930 4041818..4042819 + 1002 WP_010301809.1 tRNA-modifying protein YgfZ -
HER17_RS17935 4042874..4043521 - 648 WP_010301806.1 hemolysin III family protein -
HER17_RS17940 4043800..4044408 + 609 WP_010301802.1 HD domain-containing protein -
HER17_RS17945 4044463..4045467 + 1005 WP_010301796.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16296.29 Da        Isoelectric Point: 10.7911

>T154611 WP_029368427.1 NZ_CP051652:c4041335-4040922 [Pectobacterium carotovorum]
VALWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Download         Length: 414 bp

>T154611 NZ_CP068155:4330008-4330111 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT154611 WP_005971623.1 NZ_CP051652:c4041582-4041316 [Pectobacterium carotovorum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT154611 NZ_CP068155:c4330149-4329878 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A419ATT9

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References