Detailed information of TA system TA154487

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3574204..3574462
• Replicon: chromosome
• Accession: NZ_CP051615
• Organism: Escherichia coli O25b:H4-ST131 strain 2017_APHA

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: HHM36_RS17000
• Protein ID: WP_001181672.1
• Coordinates: 3574204..3574413 (-)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3574405..3574462 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHM36_RS16980	3569451..3570164	-	714	WP_001102393.1	acidic protein MsyB	-
HHM36_RS16985	3570190..3570594	-	405	WP_000843689.1	DUF2541 family protein	-
HHM36_RS16990	3570965..3572881	+	1917	WP_000516135.1	molecular chaperone DnaK	-
HHM36_RS16995	3572970..3574100	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
HHM36_RS17000	3574204..3574413	-	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3574405..3574462	+	58	-	-	Antitoxin
HHM36_RS17005	3574970..3575731	+	762	WP_001274833.1	hypothetical protein	-
HHM36_RS17010	3575752..3577245	+	1494	WP_001173016.1	sulfatase-like hydrolase/transferase	-
HHM36_RS17015	3577374..3578633	+	1260	WP_000494928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T154487 WP_001181672.1 NZ_CP051615:c3574413-3574204 [Escherichia coli O25b:H4-ST131]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T154487 NZ_CP068096:2766942-2767364 [Serratia plymuthica]
GTGGCCCAGTGGCGATGTAATGTCCGCATTTCCTGGCGCACCCAGCTACTCTCGCTGCTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGCTACGGCCCGATCTGGCTGGTGTTGTTGACGCTGGTGGTATTTGAATGCA
TCCGCAGCCAAAAGCGCATTGCGTCGCGGCAGGGCGAACTGCGTCTGCTGGCGAATAAGCGTTTAAGTTGGCACGGACAG
GAATGGTTGCTGGCAAAGCAACCCTGGATGCCGCGTTACGGCATTTTGCTGACGCTGCAGCCGACGCAGGGCAAAAAACG
CCGCCGGCTATGGCTGGCCTCCGACAGCATGGGCAAAGCCGAATGGCGGCATCTGCGCCAGTTGTTGCTGCACCCGTCGG
CCGATGATGACGAGGAACCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT154487 NZ_CP051615:3574405-3574462 [Escherichia coli O25b:H4-ST131]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin