Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 777102..777933 | Replicon | chromosome |
| Accession | NZ_CP051615 | ||
| Organism | Escherichia coli O25b:H4-ST131 strain 2017_APHA | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A066T988 |
| Locus tag | HHM36_RS03900 | Protein ID | WP_000854815.1 |
| Coordinates | 777559..777933 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A061Y7A8 |
| Locus tag | HHM36_RS03895 | Protein ID | WP_001280918.1 |
| Coordinates | 777102..777470 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHM36_RS03850 | 772191..772937 | + | 747 | WP_001016257.1 | IS21-like element ISEc12 family helper ATPase IstB | - |
| HHM36_RS03855 | 773020..773370 | + | 351 | Protein_759 | hypothetical protein | - |
| HHM36_RS03860 | 773386..773796 | + | 411 | WP_000846703.1 | hypothetical protein | - |
| HHM36_RS03865 | 774017..774835 | + | 819 | WP_001542275.1 | DUF945 domain-containing protein | - |
| HHM36_RS03870 | 774835..775080 | + | 246 | WP_001164966.1 | hypothetical protein | - |
| HHM36_RS03875 | 775174..775647 | + | 474 | WP_001542276.1 | antirestriction protein | - |
| HHM36_RS03880 | 775663..776139 | + | 477 | WP_001186200.1 | RadC family protein | - |
| HHM36_RS03885 | 776202..776423 | + | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| HHM36_RS03890 | 776442..777086 | + | 645 | WP_000086752.1 | hypothetical protein | - |
| HHM36_RS03895 | 777102..777470 | + | 369 | WP_001280918.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HHM36_RS03900 | 777559..777933 | + | 375 | WP_000854815.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| HHM36_RS03905 | 777930..778124 | + | 195 | WP_000988600.1 | hypothetical protein | - |
| HHM36_RS03910 | 778137..778250 | + | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| HHM36_RS03915 | 778539..778685 | - | 147 | Protein_771 | transposase domain-containing protein | - |
| HHM36_RS03920 | 778739..778921 | + | 183 | WP_001296208.1 | hypothetical protein | - |
| HHM36_RS03925 | 779022..779351 | - | 330 | WP_000450409.1 | DUF496 family protein | - |
| HHM36_RS03930 | 779523..780581 | - | 1059 | WP_001200889.1 | FUSC family protein | - |
| HHM36_RS03935 | 780779..781252 | - | 474 | WP_001105368.1 | DNA gyrase inhibitor SbmC | - |
| HHM36_RS03940 | 781309..782529 | - | 1221 | WP_000343765.1 | ISL3-like element ISEc53 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 770635..783066 | 12431 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13829.83 Da Isoelectric Point: 7.1326
>T154474 WP_000854815.1 NZ_CP051615:777559-777933 [Escherichia coli O25b:H4-ST131]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T154474 NZ_CP068090:c1961807-1961532 [Shigella boydii]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13811.70 Da Isoelectric Point: 6.4767
>AT154474 WP_001280918.1 NZ_CP051615:777102-777470 [Escherichia coli O25b:H4-ST131]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT154474 NZ_CP068090:c1961535-1961176 [Shigella boydii]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCAGCTGTTATTACCTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A066T988 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A061Y7A8 |