Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 929767..930391 Replicon chromosome
Accession NZ_CP051504
Organism Helicobacter pylori strain SHIM-011

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HG563_RS04395 Protein ID WP_202273246.1
Coordinates 929767..930033 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HG563_RS04400 Protein ID WP_001133851.1
Coordinates 930014..930391 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG563_RS04375 926418..927185 - 768 WP_000242370.1 ABC transporter ATP-binding protein -
HG563_RS04380 927185..928165 - 981 WP_000921443.1 iron ABC transporter permease -
HG563_RS04385 928158..929000 - 843 WP_202273245.1 SDR family oxidoreductase -
HG563_RS04390 929141..929665 + 525 WP_001120217.1 acyl-CoA thioesterase -
HG563_RS04395 929767..930033 - 267 WP_202273246.1 type II toxin-antitoxin system YafQ family toxin Toxin
HG563_RS04400 930014..930391 - 378 WP_001133851.1 hypothetical protein Antitoxin
HG563_RS04405 930644..932899 - 2256 WP_202273247.1 outer membrane beta-barrel protein -
HG563_RS04420 933234..933871 + 638 Protein_864 hypothetical protein -
HG563_RS04425 933822..934934 - 1113 WP_202273248.1 hydrogenase formation protein HypD -
HG563_RS04430 934957..935193 - 237 WP_202273249.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10303.17 Da        Isoelectric Point: 9.6292

>T154345 WP_202273246.1 NZ_CP051504:c930033-929767 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFKDHALKGNWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T154345 NZ_CP068018:c4987936-4987625 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14657.64 Da        Isoelectric Point: 8.7066

>AT154345 WP_001133851.1 NZ_CP051504:c930391-930014 [Helicobacter pylori]
MPNSPTKKDCTQYSEKQLFNLINQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFNNKRDCCL
GHEIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVKTQS

Download         Length: 378 bp

>AT154345 NZ_CP068018:c4987628-4987182 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References