Detailed information of TA system TA154344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ(toxin)
• Location: 272047..272635
• Replicon: chromosome
• Accession: NZ_CP051504
• Organism: Helicobacter pylori strain SHIM-011

Toxin (Protein)

• Gene name: TfiT
• Uniprot ID: M3P300
• Locus tag: HG563_RS01345
• Protein ID: WP_000921941.1
• Coordinates: 272047..272328 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: TfiA
• Uniprot ID: -
• Locus tag: HG563_RS01350
• Protein ID: WP_000065282.1
• Coordinates: 272321..272635 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG563_RS01310	267247..267510	+	264	WP_202273507.1	hypothetical protein	-
HG563_RS01315	267507..267806	+	300	WP_078286912.1	hypothetical protein	-
HG563_RS01320	267806..268747	+	942	WP_000625128.1	Flp pilus assembly complex ATPase component TadA	-
HG563_RS01325	268744..269199	+	456	WP_000795438.1	hypothetical protein	-
HG563_RS01330	269196..269486	+	291	WP_000159821.1	hypothetical protein	-
HG563_RS01335	269487..270044	+	558	WP_001167784.1	hypothetical protein	-
HG563_RS01340	270045..271772	+	1728	WP_001208201.1	type IV secretory system conjugative DNA transfer family protein	-
HG563_RS01345	272047..272328	-	282	WP_000921941.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HG563_RS01350	272321..272635	-	315	WP_000065282.1	hypothetical protein	Antitoxin
HG563_RS01355	272898..274805	+	1908	WP_202166873.1	relaxase/mobilization nuclease domain-containing protein	-
HG563_RS01360	274830..276014	-	1185	WP_202273508.1	hypothetical protein	-
HG563_RS01365	276046..276315	-	270	WP_202273509.1	hypothetical protein	-
HG563_RS01370	276400..277056	-	657	WP_000587369.1	ParA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10891.80 Da
• Isoelectric Point: 9.5726

>T154344 WP_000921941.1 NZ_CP051504:c272328-272047 [Helicobacter pylori]
MLKVRTKKDFLKDFNKHILSGRITESDVTSVVDCLKEQKPLQQKYCDHALSGNLKGLRECHVKPNLLLIYEIKKQENELV
LLRLDTHSELFKK

Nucleotide

• Length: 282 bp

>T154344 NZ_CP068018:c4585941-4585456 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12126.64 Da
• Isoelectric Point: 5.2248

>AT154344 WP_000065282.1 NZ_CP051504:c272635-272321 [Helicobacter pylori]
MSNIITDYSQYNEKQLHNFLNAIEKQLLKAEGDKKKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDNPE
CDVSFGDFNDFLQIAKQERERQDA

Nucleotide

• Length: 315 bp

>AT154344 NZ_CP068018:c4586216-4585929 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• AlphaFold DB: M3P300