Detailed information of TA system TA154205

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2518862..2519187
• Replicon: chromosome
• Accession: NZ_CP051466
• Organism: Bacillus subtilis subsp. subtilis strain UCMB5021

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: P54373
• Locus tag: HC658_RS12915
• Protein ID: WP_004398662.1
• Coordinates: 2518862..2519041 (+)
• Length: 60 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2518965..2519187 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HC658_RS12905	2518088..2518225	-	138	WP_021480099.1	hypothetical protein	-
HC658_RS12910	2518267..2518716	-	450	WP_032722171.1	phage portal protein	-
HC658_RS12915	2518862..2519041	+	180	WP_004398662.1	type I toxin-antitoxin system toxin TxpA	Toxin
-	2518965..2519187	-	223	NuclAT_0	-	Antitoxin
-	2518965..2519187	-	223	NuclAT_0	-	Antitoxin
-	2518965..2519187	-	223	NuclAT_0	-	Antitoxin
-	2518965..2519187	-	223	NuclAT_0	-	Antitoxin
HC658_RS12920	2519421..2519510	+	90	WP_075058862.1	type I toxin-antitoxin system toxin BsrH	-
HC658_RS12925	2519764..2520207	-	444	WP_003229930.1	phage tail tube protein	-
HC658_RS12930	2520210..2521610	-	1401	WP_003229929.1	phage tail sheath family protein	-
HC658_RS12935	2521611..2521802	-	192	WP_010886574.1	hypothetical protein	-
HC658_RS12940	2521799..2522236	-	438	WP_003229927.1	hypothetical protein	-
HC658_RS12945	2522249..2522752	-	504	WP_003246050.1	HK97 gp10 family phage protein	-
HC658_RS12950	2522749..2523111	-	363	WP_003229925.1	YqbH/XkdH family protein	-
HC658_RS12955	2523108..2523503	-	396	WP_004398566.1	DUF3199 family protein	-
HC658_RS12960	2523507..2523818	-	312	WP_003229923.1	YqbF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2488397..2543726	55329

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6739.19 Da
• Isoelectric Point: 8.0370

>T154205 WP_004398662.1 NZ_CP051466:2518862-2519041 [Bacillus subtilis subsp. subtilis]
MSTYESLMVMIGFANLIGGIMTWVISLLTLLFMLRKKDTHPIYITVKEKCLHEDPPIKG

Nucleotide

• Length: 180 bp

>T154205 NZ_CP067399:1843786-1844040 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 223 bp

>AT154205 NZ_CP051466:c2519187-2518965 [Bacillus subtilis subsp. subtilis]
CAAGCAAAAGTATTGCAACTACTGGCGTAAGCTTATAGTTGGTACCACATTACCACATTACCACTTGTTAATGTGTGTTA
CTTTCATGAGAAATGCTAAAATATAAAAGCCAGAGTGTGGCAGCACTCTAGCTTTTAAAAAAGAAACTACCCTTTAATAG
GAGGGTCCTCGTGTAGACACTTTTCCTTTACAGTAATGTAAATAGGATGAGTGTCTTTTTTTC

Structures

Toxin

• AlphaFold DB: A0A164X333

Antitoxin