Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3802159..3802816 Replicon chromosome
Accession NZ_CP051427
Organism Klebsiella michiganensis strain X2-1

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag HGI13_RS17955 Protein ID WP_004854060.1
Coordinates 3802406..3802816 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag HGI13_RS17950 Protein ID WP_004124953.1
Coordinates 3802159..3802425 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGI13_RS17935 3797411..3797836 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
HGI13_RS17940 3797957..3800755 - 2799 WP_154062421.1 transcriptional regulator DagR -
HGI13_RS17945 3800931..3801914 - 984 WP_004854063.1 tRNA-modifying protein YgfZ -
HGI13_RS17950 3802159..3802425 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
HGI13_RS17955 3802406..3802816 + 411 WP_004854060.1 protein YgfX Toxin
HGI13_RS17960 3802825..3803346 - 522 WP_009654974.1 flavodoxin FldB -
HGI13_RS17965 3803468..3804364 + 897 WP_154062420.1 site-specific tyrosine recombinase XerD -
HGI13_RS17970 3804387..3805100 + 714 WP_009654991.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HGI13_RS17975 3805106..3806839 + 1734 WP_209743917.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T154061 WP_004854060.1 NZ_CP051427:3802406-3802816 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T154061 NZ_CP067307:c3485762-3485364 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT154061 WP_004124953.1 NZ_CP051427:3802159-3802425 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT154061 NZ_CP067307:c3485989-3485762 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTACCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References