Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 69543..70068 Replicon plasmid p24350-2
Accession NZ_CP051388
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain CVM 24350

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag HFR97_RS24680 Protein ID WP_001159871.1
Coordinates 69763..70068 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag HFR97_RS24675 Protein ID WP_000813630.1
Coordinates 69543..69761 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFR97_RS24650 64685..65371 + 687 Protein_67 IS1 family transposase -
HFR97_RS24655 65625..66647 - 1023 WP_000361402.1 helicase UvrD -
HFR97_RS24660 66632..68197 - 1566 WP_001128474.1 AAA family ATPase -
HFR97_RS24665 68272..68688 - 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
HFR97_RS24670 68685..68915 - 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HFR97_RS24675 69543..69761 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HFR97_RS24680 69763..70068 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
HFR97_RS24685 70069..70875 + 807 WP_000016970.1 site-specific integrase -
HFR97_RS24690 71597..72352 + 756 WP_000852146.1 replication initiation protein RepE -
HFR97_RS24695 72940..74106 + 1167 WP_015059580.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120420 120420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T154042 WP_001159871.1 NZ_CP051388:69763-70068 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T154042 NZ_CP067304:c37204-37055 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT154042 WP_000813630.1 NZ_CP051388:69543-69761 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT154042 NZ_CP067304:37248-37309 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References