Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4484380..4484982 Replicon chromosome
Accession NZ_CP051368
Organism Salmonella enterica subsp. houtenae serovar 43:z4 strain CVM 24399

Toxin (Protein)


Gene name higB Uniprot ID A0A727Z0Z6
Locus tag HFS24_RS21450 Protein ID WP_000576209.1
Coordinates 4484671..4484982 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HFS24_RS21445 Protein ID WP_002954830.1
Coordinates 4484380..4484670 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HFS24_RS21430 (4481856) 4481856..4482758 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
HFS24_RS21435 (4482755) 4482755..4483390 + 636 WP_023186652.1 formate dehydrogenase cytochrome b556 subunit -
HFS24_RS21440 (4483387) 4483387..4484316 + 930 WP_000027725.1 formate dehydrogenase accessory protein FdhE -
HFS24_RS21445 (4484380) 4484380..4484670 - 291 WP_002954830.1 NadS family protein Antitoxin
HFS24_RS21450 (4484671) 4484671..4484982 - 312 WP_000576209.1 hypothetical protein Toxin
HFS24_RS21455 (4485212) 4485212..4485698 + 487 Protein_4234 alpha/beta hydrolase fold domain-containing protein -
HFS24_RS21460 (4485702) 4485702..4486643 - 942 WP_024134888.1 fatty acid biosynthesis protein FabY -
HFS24_RS21465 (4486688) 4486688..4487125 - 438 WP_000560966.1 D-aminoacyl-tRNA deacylase -
HFS24_RS21470 (4487122) 4487122..4487994 - 873 WP_000921428.1 virulence factor BrkB family protein -
HFS24_RS21475 (4487988) 4487988..4488587 - 600 WP_000965701.1 glucose-1-phosphatase -
HFS24_RS21480 (4488778) 4488778..4489581 - 804 WP_000059684.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4464829..4485355 20526


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12170.12 Da        Isoelectric Point: 9.8028

>T154027 WP_000576209.1 NZ_CP051368:c4484982-4484671 [Salmonella enterica subsp. houtenae serovar 43:z4]
MIFIETEIFTEDVKNLLDDDEYHRLQLFLAIQPDSGDLIQDAGGLRKVRWGVRGRGKRSGVRIIYFYRVSRSEIRLLLIY
KKGIKDDLTAQEKAVLRMLNERW

Download         Length: 312 bp

>T154027 NZ_CP067303:c1820531-1820424 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10693.30 Da        Isoelectric Point: 9.8827

>AT154027 WP_002954830.1 NZ_CP051368:c4484670-4484380 [Salmonella enterica subsp. houtenae serovar 43:z4]
MDKALFERLTKSMSQMNEIVEGARQPSRTFYIDAMKIKEIRQASGLSQTKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPEHVISALGC

Download         Length: 291 bp

>AT154027 NZ_CP067303:1820578-1820644 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A727Z0Z6

Antitoxin

Source ID Structure

References