Detailed information of TA system TA153976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2194572..2195122
• Replicon: chromosome
• Accession: NZ_CP051302
• Organism: Treponema denticola strain OMZ 853

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HGJ18_RS10305
• Protein ID: WP_253698329.1
• Coordinates: 2194841..2195122 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: HGJ18_RS10300
• Protein ID: WP_002665927.1
• Coordinates: 2194572..2194844 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGJ18_RS10265 (HGJ18_10300)	2189692..2190159	-	468	WP_002685268.1	flavodoxin domain-containing protein	-
HGJ18_RS10270 (HGJ18_10305)	2190236..2190691	-	456	WP_253696280.1	DUF2004 domain-containing protein	-
HGJ18_RS10275 (HGJ18_10310)	2190779..2191444	-	666	WP_253696282.1	DUF4272 domain-containing protein	-
HGJ18_RS10280 (HGJ18_10315)	2191742..2193238	+	1497	WP_253696284.1	carboxylesterase family protein	-
HGJ18_RS10285 (HGJ18_10320)	2193256..2193480	+	225	Protein_2011	SMI1/KNR4 family protein	-
HGJ18_RS10290 (HGJ18_10330)	2193738..2194307	+	570	WP_253696286.1	hypothetical protein	-
HGJ18_RS10295 (HGJ18_10335)	2194312..2194506	+	195	WP_253696288.1	hypothetical protein	-
HGJ18_RS10300 (HGJ18_10340)	2194572..2194844	+	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HGJ18_RS10305 (HGJ18_10345)	2194841..2195122	+	282	WP_253698329.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HGJ18_RS10310 (HGJ18_10350)	2195150..2195467	+	318	WP_253696290.1	hypothetical protein	-
HGJ18_RS10315 (HGJ18_10355)	2195445..2195603	+	159	WP_253696292.1	DUF2262 domain-containing protein	-
HGJ18_RS10320 (HGJ18_10360)	2195759..2196061	+	303	WP_253696294.1	hypothetical protein	-
HGJ18_RS10325 (HGJ18_10365)	2196161..2197099	+	939	WP_253696296.1	Fic family protein	-
HGJ18_RS10330 (HGJ18_10370)	2197256..2197801	+	546	WP_253696298.1	hypothetical protein	-
HGJ18_RS10335 (HGJ18_10375)	2197843..2198604	+	762	WP_002687123.1	class I SAM-dependent methyltransferase	-
HGJ18_RS10340 (HGJ18_10380)	2198558..2199955	-	1398	WP_253696300.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11123.96 Da
• Isoelectric Point: 9.8188

>T153976 WP_253698329.1 NZ_CP051302:2194841-2195122 [Treponema denticola]
IKYEIKFTNQFKKDIRLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T153976 NZ_CP067262:28576-29058 [Klebsiella variicola]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGCGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT153976 WP_002665927.1 NZ_CP051302:2194572-2194844 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT153976 NZ_CP067262:28322-28588 [Klebsiella variicola]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Antitoxin

• AlphaFold DB: Q73QD7