153974

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2478571..2479156 Replicon chromosome
Accession NZ_CP051301
Organism Treponema sp. OMZ 799

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4O04_RS11425 Protein ID WP_253708111.1
Coordinates 2478899..2479156 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E4O04_RS11420 Protein ID WP_253687140.1
Coordinates 2478571..2478906 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4O04_RS11405 (E4O04_11370) 2474827..2475606 + 780 WP_253687145.1 Nif3-like dinuclear metal center hexameric protein -
E4O04_RS11410 (E4O04_11375) 2475639..2477309 + 1671 WP_253708107.1 ATP-grasp domain-containing protein -
E4O04_RS11415 (E4O04_11380) 2477312..2478511 - 1200 WP_253708109.1 galactokinase -
E4O04_RS11420 (E4O04_11385) 2478571..2478906 - 336 WP_253687140.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E4O04_RS11425 (E4O04_11390) 2478899..2479156 - 258 WP_253708111.1 type II toxin-antitoxin system HicA family toxin Toxin
E4O04_RS11430 (E4O04_11395) 2479244..2479414 - 171 WP_253687138.1 methyltransferase -
E4O04_RS11435 (E4O04_11400) 2479415..2480029 - 615 WP_253687137.1 methyltransferase domain-containing protein -
E4O04_RS11440 (E4O04_11405) 2480046..2481749 - 1704 WP_253708113.1 galactoside ABC transporter permease -
E4O04_RS11445 (E4O04_11410) 2481774..2483267 - 1494 WP_253708115.1 sugar ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9551.88 Da        Isoelectric Point: 10.5419

>T153974 WP_253708111.1 NZ_CP051301:c2479156-2478899 [Treponema sp. OMZ 799]
VNAKNKKTFENIYKKPIPSDIFWTDIEGLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKVTDKGAVNSVRRFLENA
GVKND

Download         Length: 258 bp

>T153974 NZ_CP067261:c5402178-5401795 [Klebsiella variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12856.67 Da        Isoelectric Point: 5.6815

>AT153974 WP_253687140.1 NZ_CP051301:c2478906-2478571 [Treponema sp. OMZ 799]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFVDSVDDYLNWCREENVEPEKPYSGKFNIRISPELH
KRIAINAKRLNLSLNSFVEKALQHELTMTRI

Download         Length: 336 bp

>AT153974 NZ_CP067261:c5402420-5402178 [Klebsiella variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References