Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3509557..3510177 Replicon chromosome
Accession NZ_CP051213
Organism Salmonella enterica strain SCSW714

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag HGB43_RS17110 Protein ID WP_001280991.1
Coordinates 3509959..3510177 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag HGB43_RS17105 Protein ID WP_000344807.1
Coordinates 3509557..3509931 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGB43_RS17095 (3504696) 3504696..3505889 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HGB43_RS17100 (3505912) 3505912..3509061 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
HGB43_RS17105 (3509557) 3509557..3509931 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
HGB43_RS17110 (3509959) 3509959..3510177 + 219 WP_001280991.1 HHA domain-containing protein Toxin
HGB43_RS17115 (3510356) 3510356..3510907 + 552 WP_001278793.1 maltose O-acetyltransferase -
HGB43_RS17120 (3511025) 3511025..3511495 + 471 WP_000136183.1 YlaC family protein -
HGB43_RS17125 (3511550) 3511550..3511690 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
HGB43_RS17130 (3511696) 3511696..3511956 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
HGB43_RS17135 (3512181) 3512181..3513731 + 1551 WP_000213144.1 EAL domain-containing protein -
HGB43_RS17145 (3513962) 3513962..3514351 + 390 WP_000961285.1 MGMT family protein -
HGB43_RS17150 (3514384) 3514384..3514953 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T153816 WP_001280991.1 NZ_CP051213:3509959-3510177 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T153816 NZ_CP067124:c490652-490362 [Paracoccus alcaliphilus]
ATGCCACAACTGATCTGGTCGCCCGCGGCACTGCGAGATGTCGAACGGCTTTACCGCTTCCTTGCCGACAAGAATCCCGA
TGCCGCCCGCCGTGCGGCCAAATCCATCCGCGAGGGCATGAACATCCTGCGCGATCAACCTGGCGTCGGGCGACCGGTCG
AGGACATGGAGCCGGAATTCCGTGAATGGCTCATCGCCTTTGGCGACAGCGGTTACGTTTCTCTCTACCGGTTTGATGGC
GAAACGGCGGTGGTATTGGCCGTGCGCCATCAGCGCGAGGCGGGTTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT153816 WP_000344807.1 NZ_CP051213:3509557-3509931 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT153816 NZ_CP067124:c490924-490640 [Paracoccus alcaliphilus]
ATGAATGCCGTCCGCCCCGTTGCCGTGAAGCTCGATCAGGATACCCGCGACCGCCTCAAGCGGCTGGCGGATGCGAAGGA
TCGCTCCACCCATTGGATGCTGCGCGAGGCCGTGTCGCAGTTCGTCGAGCGCGAAGAGAAGCGTGAGGCGTTTCGTCAGG
CGGGGCTTCAGGCGTGGCAGGAATATCAGGCGACTGGCAAGCATGTCACCCATGACGAAGCCGATGCTTGGCTCGCCAGA
TTGGAAGCAGGCGAAGACGCGGCAGCTCCTGAATGCCACAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References