Detailed information of TA system TA153797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2437365..2438057
• Replicon: chromosome
• Accession: NZ_CP051206
• Organism: Dolichospermum flos-aquae CCAP 1403/13F

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HGD76_RS12135
• Protein ID: WP_168695924.1
• Coordinates: 2437365..2437625 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: HGD76_RS12140
• Protein ID: WP_148761409.1
• Coordinates: 2437719..2438057 (+)
• Length: 113 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGD76_RS12090	2433138..2434082	-	945	WP_168695920.1	DUF1848 domain-containing protein	-
HGD76_RS12095	2434257..2434457	-	201	WP_148761427.1	hypothetical protein	-
HGD76_RS12100	2434454..2434753	-	300	WP_168695921.1	BrnT family toxin	-
HGD76_RS12105	2434889..2435155	-	267	Protein_2360	type II toxin-antitoxin system Phd/YefM family antitoxin	-
HGD76_RS12110	2435457..2435735	+	279	WP_168695922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HGD76_RS12115	2435812..2436123	+	312	WP_168695923.1	HigA family addiction module antidote protein	-
HGD76_RS12120	2436165..2436320	-	156	WP_148761415.1	type II toxin-antitoxin system RelE/ParE family toxin	-
HGD76_RS12125	2436323..2436574	-	252	WP_148761413.1	type II toxin-antitoxin system ParD family antitoxin	-
HGD76_RS12130	2436798..2437016	+	219	WP_210422304.1	cobaltochelatase subunit CobN	-
HGD76_RS12135	2437365..2437625	+	261	WP_168695924.1	type II toxin-antitoxin system HicA family toxin	Toxin
HGD76_RS12140	2437719..2438057	+	339	WP_148761409.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HGD76_RS12145	2438174..2438767	+	594	WP_168695925.1	hypothetical protein	-
HGD76_RS12150	2439163..2440269	-	1107	WP_168695926.1	Gfo/Idh/MocA family oxidoreductase	-
HGD76_RS12155	2440448..2441329	-	882	WP_210967776.1	ABC transporter permease subunit	-
HGD76_RS12160	2441400..2442482	-	1083	WP_168695928.1	spermidine/putrescine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (25-83)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9594.96 Da
• Isoelectric Point: 8.6585

>T153797 WP_168695924.1 NZ_CP051206:2437365-2437625 [Dolichospermum flos-aquae CCAP 1403/13F]
MDLNNKQRKTLELIFTNPVPANIIWQDIESLFIALGAYISQGSGSRVGVKLNDVKGHFHEPHPHKETDKGTVKSVREFLT
KAGVEP

Nucleotide

• Length: 261 bp

>T153797 NZ_CP067100:c4409016-4408663 [Bradyrhizobium diazoefficiens]
TTGGCAACGAAGCCTGGTGACTATTGTCCCGAGGCCGGAGACGTCATCTGGATCGATCTGGACCCGACGGTCGGACACGA
GCAGAGGGGCCGGCGACCGGCCATCGTCGTGTCGCCGCGGAGTTACAATGCCGTCGCCGGCCTTTGCGTGATCTGCCCGA
TCACCAGTCGCGTGCGCGGTTATCCGTTCGAAGCCGTCCTGCCCGAAGATGCAAGCGTCCGTGGCGTCGTGCTTGCAGAC
CAGCCTCGGAGCATCTCCTGGGAGAAACGACCGATCACGCCTGCCGGACGGGCACCTGATGCGCTGCTCCTCGAAGTCCG
CGAACAGTTGGCTGCGTTGCTGGGAATTGAGTGA

Antitoxin

Protein

• Length: 113 a.a.
• Molecular weight: 12543.41 Da
• Isoelectric Point: 5.7723

>AT153797 WP_148761409.1 NZ_CP051206:2437719-2438057 [Dolichospermum flos-aquae CCAP 1403/13F]
MLTYKGYTASIEVDVEAGILFGRVLDINDVVTFKAKTVEEARQEFETSIDGYLAFCKELGEEPDKPFSGKLPFRTTPEHH
RKIFIAAKKAGKSINAWMDEMLINAAEKSVKA

Nucleotide

• Length: 339 bp

>AT153797 NZ_CP067100:c4409251-4408997 [Bradyrhizobium diazoefficiens]
ATGAAGGTTGCATTTCAGAAATGGGGCAACAGCCTCGCGCTGCGCGTACCGAAAGCGTTCGCCGATGAAATCGGGGCCCG
CGACGGGAGGGCGGCGGAGATGACCGTGAGCGAGGGCAAACTGGTCATCGAGATCGCGCGCGCGCAGCGGCGCAAACGTC
GCTATGCGCTGGACGATCTGGTCGCGGGGATCACGCAGGCCAACCGTCATGATGAGATCGATTGGGGGCCGGCCGTTGGC
AACGAAGCCTGGTGA