Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1644808..1645409 Replicon chromosome
Accession NZ_CP051206
Organism Dolichospermum flos-aquae CCAP 1403/13F

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HGD76_RS08035 Protein ID WP_168695458.1
Coordinates 1645128..1645409 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HGD76_RS08030 Protein ID WP_168695457.1
Coordinates 1644808..1645116 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD76_RS08010 1642447..1643001 - 555 WP_015080424.1 DNA starvation/stationary phase protection protein -
HGD76_RS08015 1643362..1643616 + 255 WP_168695454.1 hypothetical protein -
HGD76_RS08020 1643759..1644379 + 621 WP_168695455.1 (2Fe-2S) ferredoxin domain-containing protein -
HGD76_RS08025 1644496..1644771 - 276 WP_168695456.1 hypothetical protein -
HGD76_RS08030 1644808..1645116 - 309 WP_168695457.1 HigA family addiction module antidote protein Antitoxin
HGD76_RS08035 1645128..1645409 - 282 WP_168695458.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGD76_RS08040 1645814..1646503 - 690 WP_168695459.1 choice-of-anchor C family protein -
HGD76_RS08045 1646865..1647992 - 1128 WP_168695460.1 CO2 hydration protein -
HGD76_RS08050 1648051..1648467 + 417 WP_210967741.1 hypothetical protein -
HGD76_RS08055 1648453..1649949 - 1497 WP_168697395.1 NADH-quinone oxidoreductase subunit M -
HGD76_RS08060 1650010..1650299 - 290 Protein_1572 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-93)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10867.44 Da        Isoelectric Point: 7.8236

>T153795 WP_168695458.1 NZ_CP051206:c1645409-1645128 [Dolichospermum flos-aquae CCAP 1403/13F]
MIVSFSCKETEKIWQGVSSRKLPVDIQERALRKLRQLEASANLDDLRIPPGNRLEALSGDRMGEYSIRITKQWRICFIWE
NGNAYNVEIVDYH

Download         Length: 282 bp

>T153795 NZ_CP067098:4098582-4098875 [Pseudomonas sp. SW-3]
ATGAATTATATTGTTCAACAAACTATGATCTTCGTGGCATGGCATGCCTCAGTTCGTGACTTGCGGGCGAAGATTGCTAT
CGCTCGTCGCATTGATCGTGCCTCTGCAGGTAACCTGGGTGATATCAAGCCGGTGGGAGACGGCGTTTCCGAAATGCGCG
TGGACGTCGGCGCCGGCTATCGGGTCTACTTCACTTTGCGAAACAGTGTCGTCATTGTGCTTTTGGCCGGTGGTGATAAA
TCTTCGCAAACCGCCGATATCAGGCGGGCTAAAAAATTGGCAAAGGAGGTTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11790.63 Da        Isoelectric Point: 4.8177

>AT153795 WP_168695457.1 NZ_CP051206:c1645116-1644808 [Dolichospermum flos-aquae CCAP 1403/13F]
MENNLLHNPHAGEILKYEFLEELDISENTLAVNLSLTYPTIQGIITGKLKMTADIDLRLCRYFRLSDGYFLRLQNAYEIM
EAKRNLGEILNQIIPYSLLAKD

Download         Length: 309 bp

>AT153795 NZ_CP067098:4098878-4099186 [Pseudomonas sp. SW-3]
ATGAGCCAGACTTTGACTACTTTCGATATGGCGGCACTGCTGGACAGTGACGAAGCCATTAGCGAGTACCTCTCACAAGT
GCTCGCAGAGGGCGATAACGAGGAATTTCTTCGTGCTATCGGATACGTGGTGAAAGCGCGCGGAATGACACAGATTGCCA
AGGACTCGGGTATGGGTCGCGAAAGCCTGTACAAGGCCTTCGCGCCCGGTGCAAAACCACGCTTTGATACGGTTTTGAAG
GTCATCCATGCCCTCGGCATCGATCTCTGCGCGCAGCCAGGTCATTCGATCAATCACTCGGTGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References