Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 1553663..1554069 Replicon chromosome
Accession NZ_CP051206
Organism Dolichospermum flos-aquae CCAP 1403/13F

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HGD76_RS07610 Protein ID WP_168695410.1
Coordinates 1553663..1553857 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HGD76_RS07615 Protein ID WP_168695411.1
Coordinates 1553854..1554069 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGD76_RS07590 1550118..1551014 + 897 WP_168695407.1 pyridoxal-phosphate dependent enzyme -
HGD76_RS07595 1551011..1551271 - 261 WP_168642767.1 hypothetical protein -
HGD76_RS07600 1551344..1551928 - 585 WP_168695408.1 Uma2 family endonuclease -
HGD76_RS07605 1552038..1553537 - 1500 WP_168695409.1 pentapeptide repeat-containing protein -
HGD76_RS07610 1553663..1553857 + 195 WP_168695410.1 type II toxin-antitoxin system HicA family toxin Toxin
HGD76_RS07615 1553854..1554069 + 216 WP_168695411.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HGD76_RS07620 1554131..1554328 + 198 WP_168695412.1 DUF2281 domain-containing protein -
HGD76_RS07625 1554313..1554561 + 249 WP_168695413.1 type II toxin-antitoxin system PemK/MazF family toxin -
HGD76_RS07630 1554848..1556485 - 1638 WP_168697347.1 IS1634 family transposase -
HGD76_RS07635 1556721..1556861 + 141 Protein_1487 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7332.58 Da        Isoelectric Point: 10.3448

>T153794 WP_168695410.1 NZ_CP051206:1553663-1553857 [Dolichospermum flos-aquae CCAP 1403/13F]
MKVKEVLKILEEDGWYIDRIRGSHRILKHQIKSGIVVLAGKLSKDLAEGTRKSIFSQAQLEDKQ

Download         Length: 195 bp

>T153794 NZ_CP067098:c346251-345844 [Pseudomonas sp. SW-3]
ATGATCAAGTTCATGCTCGATACCAATATCTGTATTTTCACCATCAAGAACAAACCGCAAATAGTCAGAGAAGCTTTCAA
CTTGCATGACGGACAGTTATGCATCAGCGCGATTACGCTGATGGAGTTGATCTACGGTGCCGAAAAATCAGCGACCCCCG
AAAAGAACCTCGCGGTAATTGAAGGCTTCACAGCCCGCCTTGAAGTTTTCCCTTTCGACAATGAAGCAGCCGCGCATACC
GGAATGATACGGTCCGAGCTAGCGAAGGCCGGAACGCCCATTGGTCCCTATGACCAAATGATTGCCGGACATGCGCGCTC
ACGAGGGTTAATTGTCGTCACCAACAATCTGCGTGAGTTCGAACGGGTGCCAGGATTACGTGTAGAGGATTGGGTTCATC
CCGATTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7778.83 Da        Isoelectric Point: 3.8954

>AT153794 WP_168695411.1 NZ_CP051206:1553854-1554069 [Dolichospermum flos-aquae CCAP 1403/13F]
MKNYAVVYEWAGSNYSAYVPDLPGCVACGDTLQETEELIKEAIELYLEVLKEDGKPIPEPSTEVGKVAVTI

Download         Length: 216 bp

>AT153794 NZ_CP067098:c346481-346251 [Pseudomonas sp. SW-3]
ATGGAACAGACTACCCTTTTCATGAGCAATCGAAGCCAGGCTGTCCGTCTGCCGAAAGCTGTGGCGATGCCAAGTGACGT
CAAACGGGTCAACGTATTTGCCATCGGTCGGGCTCGCATCATTACGCCTGCAGACGAGACATGGGATAGCTGGTTCGATG
GAGATAACGTCAGCACAGATTTTATGACTGATCGCCAACAACCCGCCGATCAGGAGCGTGAGTCGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References