Detailed information of TA system TA153792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 1089525..1090102
• Replicon: chromosome
• Accession: NZ_CP051206
• Organism: Dolichospermum flos-aquae CCAP 1403/13F

Toxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: HGD76_RS05585
• Protein ID: WP_148763106.1
• Coordinates: 1089525..1089854 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: HGD76_RS05590
• Protein ID: WP_148763104.1
• Coordinates: 1089842..1090102 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGD76_RS05570	1085053..1085817	+	765	WP_168695200.1	flagellar motor protein	-
HGD76_RS05575	1085944..1086480	+	537	Protein_1094	cytochrome C	-
HGD76_RS05580	1086622..1089405	+	2784	WP_168695201.1	preprotein translocase subunit SecA	-
HGD76_RS05585	1089525..1089854	-	330	WP_148763106.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
HGD76_RS05590	1089842..1090102	-	261	WP_148763104.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HGD76_RS05595	1090248..1091360	+	1113	WP_168695202.1	hypothetical protein	-
HGD76_RS05600	1091491..1091718	+	228	WP_148763098.1	hypothetical protein	-
HGD76_RS05605	1091708..1092100	+	393	WP_168695203.1	type II toxin-antitoxin system VapC family toxin	-
HGD76_RS05610	1092154..1093242	-	1089	WP_168695204.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-107)

Antitoxin

• SpoVT-AbrB domain (10-52)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12235.33 Da
• Isoelectric Point: 7.1338

>T153792 WP_148763106.1 NZ_CP051206:c1089854-1089525 [Dolichospermum flos-aquae CCAP 1403/13F]
MAMVVNRFDVFLVNLDPTIGSEIKKTRPCLIISPNEINHHIATVIVAPMTTKGQPYPTRVTCQFQGQNGQIVLDQIRTVD
KTRLVKLLGQITTEEQKTVLDILAEMFAE

Nucleotide

• Length: 330 bp

>T153792 NZ_CP067095:c141616-141134 [Klebsiella michiganensis]
GTGGGATGTATAACAGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGAGAAACGGTACTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAGGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATATCTCATTGCACGTAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGCTTCTATGTTCACCATGGATTTAAGGCATCACAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9955.34 Da
• Isoelectric Point: 4.8430

>AT153792 WP_148763104.1 NZ_CP051206:c1090102-1089842 [Dolichospermum flos-aquae CCAP 1403/13F]
MGTAIKTRIVKIGNSQGLRIPKTLLEQSGINSEVEIEVHGNHLIIRPVTQIRKGWEKAFIEMAEKQDDVLLDDINTTEWD
KDEWQW

Nucleotide

• Length: 261 bp

>AT153792 NZ_CP067095:c141870-141604 [Klebsiella michiganensis]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA