Detailed information of TA system TA153775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpIK/PemK(toxin)
• Location: 2534482..2535049
• Replicon: chromosome
• Accession: NZ_CP051198
• Organism: Treponema sp. OMZ 787

Toxin (Protein)

• Gene name: chpK
• Uniprot ID: -
• Locus tag: E4O05_RS11865
• Protein ID: WP_253678142.1
• Coordinates: 2534708..2535049 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: chpI
• Uniprot ID: -
• Locus tag: E4O05_RS11860
• Protein ID: WP_253722278.1
• Coordinates: 2534482..2534721 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4O05_RS11840 (E4O05_11760)	2531431..2532360	+	930	WP_253722276.1	Hsp33 family molecular chaperone HslO	-
E4O05_RS11845 (E4O05_11765)	2532350..2532973	+	624	WP_253693482.1	precorrin-8X methylmutase	-
E4O05_RS11850 (E4O05_11770)	2533014..2533729	-	716	Protein_2328	Rpn family recombination-promoting nuclease/putative transposase	-
E4O05_RS11855 (E4O05_11775)	2533986..2534291	+	306	WP_253722277.1	hypothetical protein	-
E4O05_RS11860 (E4O05_11780)	2534482..2534721	+	240	WP_253722278.1	hypothetical protein	Antitoxin
E4O05_RS11865 (E4O05_11785)	2534708..2535049	+	342	WP_253678142.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
E4O05_RS11870 (E4O05_11790)	2535100..2536719	-	1620	WP_253722279.1	ATP-binding protein	-
E4O05_RS11875 (E4O05_11795)	2536799..2538457	-	1659	WP_253722280.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-111)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12648.92 Da
• Isoelectric Point: 10.0501

>T153775 WP_253678142.1 NZ_CP051198:2534708-2535049 [Treponema sp. OMZ 787]
MMRGELWFADLGIPFGSETGYRRPVIIMQNDLFNVSKIRTIEVVPLTTNLILGEAPGNVIINKKNSKLPKDSVAVVSQLT
AIDKTRFIEKIGKINKNLIKEIESGIRLVLDIE

Nucleotide

• Length: 342 bp

>T153775 NZ_CP067091:c3618019-3617744 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9116.24 Da
• Isoelectric Point: 4.5556

>AT153775 WP_253722278.1 NZ_CP051198:2534482-2534721 [Treponema sp. OMZ 787]
MKTAVSISDSLFLRAQKFQTNCNISRSKLYSDALDEYLSKREKQDITAQLNSVYEQIETEDELNIGLLALRELTKNDAW

Nucleotide

• Length: 240 bp

>AT153775 NZ_CP067091:c3618282-3618022 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA