Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1770218..1770837 Replicon chromosome
Accession NZ_CP051195
Organism Treponema sp. OMZ 803 strain BF2M

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ABH09_RS07975 Protein ID WP_162664818.1
Coordinates 1770523..1770837 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ABH09_RS07970 Protein ID WP_253713997.1
Coordinates 1770218..1770526 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH09_RS07950 (ABH09_07935) 1765550..1766062 - 513 WP_253713993.1 TIGR03546 family protein -
ABH09_RS07955 (ABH09_07945) 1766661..1767347 + 687 WP_253713994.1 outer membrane lipoprotein carrier protein LolA -
ABH09_RS07960 (ABH09_07950) 1767430..1768548 + 1119 WP_253713995.1 helix-turn-helix domain-containing protein -
ABH09_RS07965 (ABH09_07955) 1768541..1770124 + 1584 WP_253713996.1 MiaB/RimO family radical SAM methylthiotransferase -
ABH09_RS07970 (ABH09_07960) 1770218..1770526 - 309 WP_253713997.1 NadS family protein Antitoxin
ABH09_RS07975 (ABH09_07965) 1770523..1770837 - 315 WP_162664818.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ABH09_RS07985 (ABH09_07975) 1771715..1773367 + 1653 WP_253713998.1 nucleoside kinase -
ABH09_RS07990 (ABH09_07980) 1773394..1774524 - 1131 WP_253713999.1 glycosyltransferase -
ABH09_RS07995 (ABH09_07985) 1774694..1775272 - 579 WP_253714000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11961.14 Da        Isoelectric Point: 10.3625

>T153759 WP_162664818.1 NZ_CP051195:c1770837-1770523 [Treponema sp. OMZ 803]
MELIETPVFKKQIDRLLDDLTYTQFKEYLVCNPLKGKLIRGGGGIRKIRWGKKNTGKSGGVRIIYFIKTDTQIYLLFAYA
KNESDNLTKKQTNMLAAFVKEVLL

Download         Length: 315 bp

>T153759 NZ_CP067073:c959089-958796 [Rhizobium sp. AB2/73]
GTGCCACGAGTGATCGTTACCGAAGGTGCGGCACAGGGTTTGGAGCGCTGCAGGCGATTTCTGGCGGCTAAGGCGCCGAC
TGCCGCAAGTCGGGCGGGCCGGGCTATCGAACGCCAGTTCCTGTTACTGGAATCAACGCCTCTTATTGGCCGCCCGCTTC
CGGACGACGCGCAATTGCGTGAACTGGTGATTCCCTTTGGGGACTCCGGCTACGTCGCGCTTTACCGACATGAGCCTGAT
GGCGATATCGTGTTTGTCCTCGCTTTCCGACATCAGAAAGAGGCTGGCTACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11438.26 Da        Isoelectric Point: 7.2050

>AT153759 WP_253713997.1 NZ_CP051195:c1770526-1770218 [Treponema sp. OMZ 803]
MIGHKKMSDEMFSELIQSIKEAALIEKGEMEPARVSVIDALDIAAIRNKTHKTQEEFATMLNISIGTLRNWEQGRRKPDG
AALSLLKVVSADPQYVEKVLRT

Download         Length: 309 bp

>AT153759 NZ_CP067073:c959349-959077 [Rhizobium sp. AB2/73]
ATGGCTACTTCTCTCAAGATTGATGACGAGCTAAAGAACCGAGTTCAGAACCTCGCCAGCCAAAGACGGCGCTCGGCACA
CTGGATCATCCTCGAAGCCATTCAGCAGTATGTCGAACGTGAGGAAGCGCGCGAAAACTTCAAACAGGAGGCTTTGGCAT
CCTGGGCGGCCTATCAGGAGACCGGCCGACATCTTACCGGACAGGAGGTACGCACTTGGCTGGACACCTGGGGCACCGAT
GCGGAAGAGACGGTACCTGAGTGCCACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References