Detailed information of TA system TA153719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 287292..287953
• Replicon: chromosome
• Accession: NZ_CP051175
• Organism: Ralstonia solanacearum strain Rs5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A399W071
• Locus tag: HF906_RS01320
• Protein ID: WP_003278076.1
• Coordinates: 287292..287705 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HF906_RS01325
• Protein ID: WP_003270753.1
• Coordinates: 287702..287953 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF906_RS01285	282871..283578	+	708	WP_193010382.1	hypothetical protein	-
HF906_RS01290	283587..283979	+	393	WP_003270231.1	hypothetical protein	-
HF906_RS01295	283976..284197	+	222	WP_003270229.1	hypothetical protein	-
HF906_RS01300	284172..284816	+	645	WP_003270228.1	hypothetical protein	-
HF906_RS01305	284859..285149	-	291	WP_014617596.1	H-NS histone family protein	-
HF906_RS01310	285343..286806	-	1464	WP_119447092.1	YOPP/AvrRxv family protein	-
HF906_RS01315	287054..287287	+	234	WP_075453126.1	hypothetical protein	-
HF906_RS01320	287292..287705	-	414	WP_003278076.1	type II toxin-antitoxin system VapC family toxin	Toxin
HF906_RS01325	287702..287953	-	252	WP_003270753.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HF906_RS01330	288028..288213	+	186	WP_193010383.1	hypothetical protein	-
HF906_RS01335	288224..288493	+	270	WP_075453129.1	hypothetical protein	-
HF906_RS01340	288431..288973	-	543	WP_143169726.1	hypothetical protein	-
HF906_RS01345	289083..289379	-	297	WP_143169727.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	260004..293949	33945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15756.12 Da
• Isoelectric Point: 6.2337

>T153719 WP_003278076.1 NZ_CP051175:c287705-287292 [Ralstonia solanacearum]
MSYLIDTNVLSELRRKQPDARVLAWMQDRPRQSLYLSVLTLGEIRKGIERLDDAARRQHLIDWLETELPNYFLGRLLDID
AHTADRWGRLMSSANRPLPAIDGLLAATALQHDLILVTRNTKDFVGLDVPLINPWET

Nucleotide

• Length: 414 bp

>T153719 NZ_CP067058:c63129-62863 [Rahnella aceris]
ATGAAAACGCGATTCACTAAGAGAGGGGCAGCCGATTATCAATACTGGCAGGGAAGTAACGCCAAAATATTCGAGCGCAT
CCGTATACTGATACATGCGATTCATGCCGACCCACTGGGCGGTATTGGTAAGCCAGAACGGTTGCGCCATTATAAAAATC
CGGCACTTTATTCCCGGCGCATAGACAGAGAACACCGACTTGTTTACAGCATGGTAAATGATGAATTAACTATAATTGCC
TGCCGGTATCATTATGACGATGTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9272.49 Da
• Isoelectric Point: 5.0774

>AT153719 WP_003270753.1 NZ_CP051175:c287953-287702 [Ralstonia solanacearum]
MQSWQLQTAKARFSDVVKRAADDGPQEITVHGRPVAVVISRALFDRLSGGGESLVDFMRQSPLAGLDDVVFERERSLPRE
VEF

Nucleotide

• Length: 252 bp

>AT153719 NZ_CP067058:c63371-63126 [Rahnella aceris]
ATGCATTCATTAACGTTTACTGATGCCCGTAAGCATTTTGCTGAGACAATGCAGCAGGTTAGCGACAATGCCGAGCCCGT
GCGTATTCTGCGACGTGATGCTCCTGATGTTGTACTGATTGACGCCGCCGAATATGACGCTATTTTAGAAACACTATATT
TATTCAGCAATCCTGCGAACGCTGCACATATTAACGCATCGCTGGCTGAGTTAGATCGCGGTGACACTGTCGAAATTGAA
GTATGA

Structures

Toxin

• AlphaFold DB: A0A399W071