Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 452237..452870 Replicon chromosome
Accession NZ_CP051173
Organism Ralstonia solanacearum strain UW763

Toxin (Protein)


Gene name vapC Uniprot ID M4UIT8
Locus tag HF907_RS02060 Protein ID WP_016725172.1
Coordinates 452457..452870 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag HF907_RS02055 Protein ID WP_011002949.1
Coordinates 452237..452470 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF907_RS02040 447825..449120 - 1296 WP_011002952.1 MFS transporter -
HF907_RS02045 449128..450378 - 1251 WP_111375179.1 AGE family epimerase/isomerase -
HF907_RS02050 450573..452180 + 1608 WP_064478112.1 glucan biosynthesis protein -
HF907_RS02055 452237..452470 + 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HF907_RS02060 452457..452870 + 414 WP_016725172.1 PIN domain-containing protein Toxin
HF907_RS02065 452845..453471 - 627 WP_019718918.1 DUF1415 family protein -
HF907_RS02070 453662..454033 + 372 WP_016725174.1 hypothetical protein -
HF907_RS02075 454097..455593 - 1497 WP_011002945.1 glycerol kinase GlpK -
HF907_RS02080 455755..457491 - 1737 WP_064478111.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15087.42 Da        Isoelectric Point: 5.5348

>T153715 WP_016725172.1 NZ_CP051173:452457-452870 [Ralstonia solanacearum]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVSVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

>T153715 NZ_CP067057:3677639-3677923 [Rahnella aceris]
ATGACTTATAAACTCAATTTTTTCAAATCAGCTTTAAAAGAATGGAAAGCACTTGCCCCAACGATCAAGGAGCAATTTAA
AAAGAAACTGGCCGAGCGGCTGGAGAATCCTCACGTGGTTTCTGCCCGCTTATGTGGCCCCAAAAATAACCGCTATAAAA
TCAAATTAAAGAGTCTTGGTTATCGCCTGGTGTATCAGGTAGAAGATCAGGAAATCATCGTGACCGTTGTCGCGGTGGGT
AAACGCGAAGGCAACGAAGCGTATAAACTGGCTGAGAAGCGCTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT153715 WP_011002949.1 NZ_CP051173:452237-452470 [Ralstonia solanacearum]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp

>AT153715 NZ_CP067057:3677401-3677649 [Rahnella aceris]
ATGCCGTTTGAAATACTCACTTCCTCAGCCGCCAGTATTACTGAACTAAAACGCGACCCGATGGGAACATTTAGTGCAGG
CGAAGGCGAAGCGGTGGCGATACTCAATCGTAACGAGCCCGCTTTTTATTGCGTTCCGCCCGATGTTTACGCCTATTTTC
TGAGTCTTGCAGAAGACGTTGAATTGAACCGCATAATGGATGCGCGGCAGGGTGAAGAAAGGATAAGGCTGACACTGGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4UIT8

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References