Detailed information of TA system TA153535

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2728364..2728652
• Replicon: chromosome
• Accession: NZ_CP051005
• Organism: Enterococcus faecalis strain TH4125

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: GRB94_RS13480
• Protein ID: WP_168754334.1
• Coordinates: 2728524..2728652 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2728364..2728575 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GRB94_RS13455	2724049..2725002	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
GRB94_RS13460	2725041..2725796	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
GRB94_RS13465	2725793..2726758	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
GRB94_RS13470	2726755..2727701	-	947	Protein_2620	iron chelate uptake ABC transporter family permease subunit	-
GRB94_RS13475	2727886..2728338	+	453	WP_002378807.1	YueI family protein	-
-	2728364..2728575	+	212	-	-	Antitoxin
GRB94_RS13480	2728524..2728652	-	129	WP_168754334.1	putative holin-like toxin	Toxin
GRB94_RS13485	2728815..2731085	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
GRB94_RS13490	2731256..2731762	+	507	WP_002378810.1	cysteine hydrolase	-
GRB94_RS13495	2731952..2732848	+	897	WP_002365354.1	YitT family protein	-
GRB94_RS13500	2732899..2733297	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4773.67 Da
• Isoelectric Point: 5.6470

>T153535 WP_168754334.1 NZ_CP051005:c2728652-2728524 [Enterococcus faecalis]
MHFNERSIFLSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T153535 NZ_CP066949:c4707815-4707663 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin

Nucleotide

• Length: 212 bp

>AT153535 NZ_CP051005:2728364-2728575 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin