Detailed information of TA system TA153511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 2637185..2637664
• Replicon: chromosome
• Accession: NZ_CP051001
• Organism: Escherichia coli O157:H16 str. 98-3133

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: -
• Locus tag: BY40_RS12795
• Protein ID: WP_001373944.1
• Coordinates: 2637185..2637472 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: BY40_RS12800
• Protein ID: WP_001300743.1
• Coordinates: 2637473..2637664 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BY40_RS12765 (2632305)	2632305..2632547	-	243	WP_000273151.1	DUF4224 domain-containing protein	-
BY40_RS12770 (2632615)	2632615..2635050	-	2436	WP_000048584.1	exonuclease	-
BY40_RS12775 (2635144)	2635144..2635335	-	192	WP_001098307.1	DUF1482 family protein	-
BY40_RS12780 (2635332)	2635332..2635520	-	189	WP_000413705.1	cell division inhibition protein DicB	-
BY40_RS12785 (2636224)	2636224..2636670	+	447	WP_000373334.1	hypothetical protein	-
BY40_RS12790 (2636769)	2636769..2636921	-	153	WP_000367377.1	DUF1391 family protein	-
BY40_RS12795 (2637185)	2637185..2637472	-	288	WP_001373944.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BY40_RS12800 (2637473)	2637473..2637664	-	192	WP_001300743.1	hypothetical protein	Antitoxin
BY40_RS12805 (2637633)	2637633..2638094	-	462	WP_000538413.1	helix-turn-helix domain-containing protein	-
BY40_RS12810 (2638125)	2638125..2638496	-	372	WP_000448218.1	hypothetical protein	-
BY40_RS12815 (2638599)	2638599..2638880	+	282	WP_021577226.1	YdaS family helix-turn-helix protein	-
BY40_RS12820 (2638884)	2638884..2639309	+	426	WP_000693855.1	toxin YdaT family protein	-
BY40_RS12825 (2639516)	2639516..2639971	-	456	WP_001486451.1	hypothetical protein	-
BY40_RS12830 (2640050)	2640050..2641165	+	1116	WP_001205821.1	hypothetical protein	-
BY40_RS12835 (2641172)	2641172..2641918	+	747	WP_000788753.1	ATP-binding protein	-
BY40_RS12840 (2641940)	2641940..2642119	+	180	Protein_2511	hypothetical protein	-
BY40_RS12845 (2642116)	2642116..2642457	+	342	Protein_2512	DUF968 domain-containing protein	-
BY40_RS12850 (2642457)	2642457..2642540	+	84	Protein_2513	antiterminator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	nleB2	2623953..2652507	28554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10955.69 Da
• Isoelectric Point: 6.7144

>T153511 WP_001373944.1 NZ_CP051001:c2637472-2637185 [Escherichia coli O157:H16 str. 98-3133]
MLPVLWLESADADLDNITSYIARFDIDAAERLWKRLRTCVLPLSEHPYLYPPSDRVPGLRETVAHPNYIILYRVTISGIE
IVNVVHARRQFPVTP

Nucleotide

• Length: 288 bp

>T153511 NZ_CP066936:c4688718-4688584 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7350.26 Da
• Isoelectric Point: 5.8256

>AT153511 WP_001300743.1 NZ_CP051001:c2637664-2637473 [Escherichia coli O157:H16 str. 98-3133]
MNTALSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVERRMAERFANMRKERSKQ

Nucleotide

• Length: 192 bp

>AT153511 NZ_CP066936:c4688947-4688795 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA