Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11794..12437 Replicon plasmid pSI102-2
Accession NZ_CP050773
Organism Salmonella enterica subsp. enterica serovar Indiana strain SI102

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag HEC79_RS23970 Protein ID WP_001044768.1
Coordinates 12021..12437 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag HEC79_RS23965 Protein ID WP_001261287.1
Coordinates 11794..12024 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HEC79_RS23945 6954..8042 + 1089 WP_000952217.1 transcriptional repressor PifC -
HEC79_RS23950 8044..10269 + 2226 WP_000698737.1 phage T7 exclusion protein -
HEC79_RS23955 10319..11218 - 900 WP_000963206.1 nucleotide-binding protein -
HEC79_RS23960 11208..11498 - 291 WP_000111771.1 hypothetical protein -
HEC79_RS23965 11794..12024 + 231 WP_001261287.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HEC79_RS23970 12021..12437 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
HEC79_RS23975 12599..14737 - 2139 WP_000350638.1 AAA family ATPase -
HEC79_RS23980 15091..15348 + 258 WP_000343085.1 hypothetical protein -
HEC79_RS23985 15348..15938 + 591 WP_000194575.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34285 34285


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-288)

Antitoxin

Transcription regulator IclR, C-terminal

(137-258)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 17834.22 Da        Isoelectric Point: 12.9398

>T153165 WP_001044768.1 NZ_CP050773:12021-12437 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 417 bp

>T153165 NZ_CP066772:c1342852-1341950 [Ralstonia pickettii]
ATGAACGCGCAGGCTGTCATGTCCTCCCATCCGTTCCGCGTGGCCGACGCGCTTGCCGTGCTCGGCGCGGGGTTTGTCGA
ACGCACCGTCGCCATTAACGACCACGGCGATCGCATCGGCTATCGGCAATGGGGCGAGCGCGGACCGCTGGTGGTGCTAT
TGCACGGCATCAGCTCCAGCGCTGCGTCATGGCTGCCTTGCGCGCAGGTTCTTTCGCACAACATGCGCGTGCTGGCATGG
GATGCGCCGGGCTACGGCAGCTCCACGCCGCTTGCAGACGTTGCACCGCGCGCTGCCGACTACGCTGGGCGATTGCAGGC
GTGGCTTGCCGCGCTGGATGTGACGCCCGATGTGATCGTCGGTCATTCACTGGGCGCGCTGATGGCATCGGCGTATGTGG
CCGCCGCACCAGCCGCGATGCAGCCGAAATGCCTGATGTTGCTGAACCCCGCGCAGGGCTATGGCCAGCCGGGGCAGGAA
GATCAATCCCGCAGCGTGCAGGCCCAGCGTCTTGCAACGCTCGACCAGCTTGGCATCGACGGCATGGCGGAGTCGCGCCA
CGCGCATCTGCTGCGCCCGAATGCCACCGACGAAGAACGCGCCTGGGTGCGTTGGAACATGAAGCGCCTCAACGACGGTG
GCTATCGCCAGGCCGTGGCGATGTTGAGCGGCGACGACATCGGCGCCTATCTGAGCAAACGCCCCGCATCCACACCCGCA
CAGATTGCTTGCGGCGACGTCGACGGCATTACACCGCCGGAAGGTTGCGAAGCGCTGGCCAAGATGTTCGATCTGCCGTT
TGCGCTTGTGCCATCGGCGGGGCATGCCTCCTATATCGATGCGCCTGACGCTGTTGCAGGCTGGATCGAACACGCTGTTC
TCTCCCAATCCCAAAACGCCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT153165 WP_001261287.1 NZ_CP050773:11794-12024 [Salmonella enterica subsp. enterica serovar Indiana]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT153165 NZ_CP066772:c1341937-1341110 [Ralstonia pickettii]
ATGAGCAACGACCTCATCCCAGAAGACGTGCAGGAAAAGTACATCGTGCCGGGGCTCGAACGCGGCCTGCGCCTGCTGTG
CGAGTTCAGCCACAAAGACCGTGTCCTGTCTGCACCTGAACTGGCGCGCCGCCTGAAGGTGCCGCGCTCCACGGTGTTCC
GCCTGCTGACCACACTCGAAGTGATGGGCTTCATCGAACGCGTTGACGGCGGCCGCGATTTTCGCCTCGGCATGGCGGTG
CTGCGCCTGGGCTTTGAATATCTCGCGTCGCTGGAATTGACCGAGCTGGGCCGTCCGCTGCTCGATCGCCTGCGCGACGA
CATTCATTACCCATGCAACCTCGTCGTGCGCGATGGCCGCTCGATCGTCTACGTGGCGAAATCCGTCGCGCCCACGCCGT
TCACCAGTTCGGTGAATGTCGGCACGCGCCTGCCGGCACACGCCACGGTGCTGGGCCGTGTGCTGCTGGCAGACCTGTCG
CTGGCGGAATTGCGCCAGCTCTATCCGGAGCCGCAGCTGGAGGTGTTCTCCGCCAACACGCCGCGCACGGTGGAAGAACT
GTTCGTGATGGTCCAGCGCGACCGCGAACACGGCTACGTGCTGCAGGAAGGCTTCTTCGAAGCCAACATCTCGACGATTG
CTGCGCCAGTGCTCGACCGCGCCGGCAAGGTGGTGGCCGCGCTCGGTACGACGATTCCGTCGCCGCGCATCGAGGCAGCT
CAGCTCGATCTGATGATCGACAAGGTGCGCGCTGCTGCCGGCGAGCTGTCTTACTTGCTGGACTACCGCCCCGCCAGCGG
CAAGGTCGTCAACCTGTTCCGCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References