Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2721736..2722262 Replicon chromosome
Accession NZ_CP050508
Organism Raoultella terrigena strain JH01

Toxin (Protein)


Gene name relE Uniprot ID A0A4U9CTU1
Locus tag HCK03_RS12805 Protein ID WP_041145684.1
Coordinates 2721975..2722262 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6D1SE57
Locus tag HCK03_RS12800 Protein ID WP_041145685.1
Coordinates 2721736..2721975 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCK03_RS12775 2717058..2717951 - 894 WP_167691680.1 LysR family transcriptional regulator -
HCK03_RS12780 2718083..2718238 - 156 Protein_2493 diaminopimelate epimerase -
HCK03_RS12785 2718540..2720234 + 1695 WP_123552271.1 thiamine pyrophosphate-binding protein -
HCK03_RS12790 2720231..2721151 - 921 WP_041145686.1 LysR family transcriptional regulator -
HCK03_RS12795 2721221..2721539 - 319 Protein_2496 histidine phosphatase family protein -
HCK03_RS12800 2721736..2721975 + 240 WP_041145685.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
HCK03_RS12805 2721975..2722262 + 288 WP_041145684.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
HCK03_RS12810 2722333..2722491 + 159 WP_064349756.1 type I toxin-antitoxin system Hok family toxin -
HCK03_RS12815 2722878..2723318 + 441 WP_167692436.1 GNAT family N-acetyltransferase -
HCK03_RS12820 2723926..2724369 + 444 WP_041145682.1 acetyltransferase -
HCK03_RS12825 2724389..2724973 - 585 WP_167691681.1 XRE family transcriptional regulator -
HCK03_RS12830 2725594..2726493 - 900 WP_167691682.1 transcriptional regulator GcvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2713205..2727956 14751


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11149.10 Da        Isoelectric Point: 10.1967

>T152988 WP_041145684.1 NZ_CP050508:2721975-2722262 [Raoultella terrigena]
MAYFLDFDERALKEWRKLGSTVREQLKKKLAEVLESPRIEANKLRGVPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERAEVYSEAVKRIL

Download         Length: 288 bp

>T152988 NZ_CP066711:809515-809736 [Staphylococcus pseudintermedius]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGTCTGTTGCTATTGATGTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9097.56 Da        Isoelectric Point: 4.5348

>AT152988 WP_041145685.1 NZ_CP050508:2721736-2721975 [Raoultella terrigena]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIAENERLPFKQILLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT152988 NZ_CP066711:809215-809502 [Staphylococcus pseudintermedius]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTGTTGACGCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGATGCATCAAGCATAAGATTGACGCGGGACACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACATTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U9CTU1

Antitoxin

Source ID Structure
AlphaFold DB A0A6D1SE57

References