Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2968346..2969181 Replicon chromosome
Accession NZ_CP050498
Organism Escherichia coli strain RM13322

Toxin (Protein)


Gene name yeeV Uniprot ID F2VI91
Locus tag HCR07_RS15430 Protein ID WP_000854748.1
Coordinates 2968804..2969181 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H0IVG5
Locus tag HCR07_RS15425 Protein ID WP_001339471.1
Coordinates 2968346..2968714 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCR07_RS15390 2963721..2965106 + 1386 Protein_3021 hypothetical protein -
HCR07_RS15395 2965182..2965637 + 456 WP_000581504.1 hypothetical protein -
HCR07_RS15400 2965716..2965949 + 234 WP_001119729.1 DUF905 family protein -
HCR07_RS15405 2966049..2966867 + 819 WP_001234620.1 DUF945 domain-containing protein -
HCR07_RS15410 2966922..2967407 + 486 WP_000849570.1 antirestriction protein -
HCR07_RS15415 2967423..2967899 + 477 WP_001186727.1 RadC family protein -
HCR07_RS15420 2967962..2968183 + 222 WP_000692345.1 DUF987 domain-containing protein -
HCR07_RS15425 2968346..2968714 + 369 WP_001339471.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HCR07_RS15430 2968804..2969181 + 378 WP_000854748.1 TA system toxin CbtA family protein Toxin
HCR07_RS15435 2969178..2969666 + 489 WP_000761721.1 hypothetical protein -
HCR07_RS15440 2969678..2969875 + 198 WP_000839281.1 DUF957 domain-containing protein -
HCR07_RS15445 2969972..2970544 + 573 WP_001290246.1 DUF4942 domain-containing protein -
HCR07_RS15450 2971293..2972831 + 1539 WP_001187182.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14179.16 Da        Isoelectric Point: 7.7761

>T152946 WP_000854748.1 NZ_CP050498:2968804-2969181 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T152946 NZ_CP066637:514182-514523 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13517.22 Da        Isoelectric Point: 6.4789

>AT152946 WP_001339471.1 NZ_CP050498:2968346-2968714 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT152946 NZ_CP066637:513952-514182 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F2VI91

Antitoxin

Source ID Structure
AlphaFold DB A0A0H0IVG5

References