Detailed information of TA system TA152928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2331195..2331745
• Replicon: chromosome
• Accession: NZ_CP050497
• Organism: Treponema vincentii strain OMZ 806

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GWP40_RS10565
• Protein ID: WP_212565302.1
• Coordinates: 2331195..2331476 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C8PQ87
• Locus tag: GWP40_RS10570
• Protein ID: WP_006188742.1
• Coordinates: 2331473..2331745 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GWP40_RS10535 (GWP40_10560)	2327430..2328023	-	594	WP_212565298.1	MBL fold metallo-hydrolase	-
GWP40_RS10540 (GWP40_10565)	2328020..2328472	-	453	WP_230974413.1	pentapeptide repeat-containing protein	-
GWP40_RS10545 (GWP40_10570)	2328874..2329443	-	570	WP_212565300.1	histidine phosphatase family protein	-
GWP40_RS13015	2329429..2329770	+	342	WP_230974414.1	hypothetical protein	-
GWP40_RS10555 (GWP40_10580)	2329763..2330077	+	315	WP_016523404.1	helix-turn-helix domain-containing protein	-
GWP40_RS10560 (GWP40_10585)	2330083..2331117	-	1035	WP_212565301.1	LD-carboxypeptidase	-
GWP40_RS10565 (GWP40_10590)	2331195..2331476	-	282	WP_212565302.1	type II toxin-antitoxin system YafQ family toxin	Toxin
GWP40_RS10570 (GWP40_10595)	2331473..2331745	-	273	WP_006188742.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GWP40_RS10575 (GWP40_10600)	2331893..2332357	-	465	WP_212565303.1	hypothetical protein	-
GWP40_RS10580 (GWP40_10605)	2332341..2332646	-	306	WP_212565304.1	hypothetical protein	-
GWP40_RS10585 (GWP40_10610)	2333350..2334393	-	1044	WP_212565305.1	beta-eliminating lyase-related protein	-
GWP40_RS10590 (GWP40_10615)	2334542..2336302	+	1761	WP_212565306.1	threonine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-68)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11059.89 Da
• Isoelectric Point: 9.6113

>T152928 WP_212565302.1 NZ_CP050497:c2331476-2331195 [Treponema vincentii]
MKYEVKFTTQFKKDLKLAKKQNKNLDKLLEVINLLSNGEKLEAKYRDHDLSGSYKGTRECHIEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T152928 NZ_CP066600:50717-51067 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10113.61 Da
• Isoelectric Point: 4.6017

>AT152928 WP_006188742.1 NZ_CP050497:c2331745-2331473 [Treponema vincentii]
MATTNLNIRTDKEMKEQAEAIFFELGLTMTTAINMFLRTTIRENGIPFALKLDIPNATTVSAIEEGRKIAYDDSVKGYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT152928 NZ_CP066600:50460-50723 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Structures

Antitoxin

• AlphaFold DB: C8PQ87