Detailed information of TA system TA152864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3133129..3133808
• Replicon: chromosome
• Accession: NZ_CP050425
• Organism: Acinetobacter baumannii strain PM194188

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: HB368_RS15175
• Protein ID: WP_000838146.1
• Coordinates: 3133626..3133808 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: HB368_RS15170
• Protein ID: WP_000966688.1
• Coordinates: 3133129..3133533 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HB368_RS15165	3132520..3133029	-	510	WP_000734512.1	hypothetical protein	-
HB368_RS15170	3133129..3133533	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HB368_RS15175	3133626..3133808	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
HB368_RS15180	3134134..3134649	-	516	WP_150408856.1	hypothetical protein	-
HB368_RS15185	3134719..3135636	-	918	WP_038346476.1	hypothetical protein	-
HB368_RS15190	3135733..3136875	-	1143	WP_150408857.1	fibronectin type III domain-containing protein	-
HB368_RS15195	3136875..3137228	-	354	WP_031958856.1	hypothetical protein	-
HB368_RS15200	3137297..3137695	-	399	WP_009517131.1	hypothetical protein	-
HB368_RS15205	3137697..3138065	-	369	WP_032016325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3118986..3180346	61360

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T152864 WP_000838146.1 NZ_CP050425:c3133808-3133626 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T152864 NZ_CP066552:977028-977444 [Pectobacterium carotovorum]
GTGAGTCGCTTGTTCATGCTGGATACCAATATCTGTTCCTTCATTATGCGTGAACACCCTGCGGAGGTGATTGAAAAGTT
GCAGCAGTGCACGCTGCGGCGTGATCGGATTGTGGTCTCTGCCAGCACTTACGCTGAAATGCGTTTCGGGGCGGTTGGCA
AAAAAGCCTCGCCACGCCATATGCAACTCGTTGATGCTTTCTGTCGCCGGCTCGATGCGGTGTTACCTTGGGATAGCGCC
GCAGTAGATGCCACCACGAAAATCAAAATCGCGCTAGCCGCCGCTGGCACACCTATTGGTCCAAACGATACGGCCATCGC
GGGCCATGCCATCAGCGCTAAGGCCATATTAGTCACCAATAATCTGAGAGAATTTGAGCGAGTACCGGGGCTGACGTTGG
AAGATTGGGTTAAATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT152864 WP_000966688.1 NZ_CP050425:c3133533-3133129 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT152864 NZ_CP066552:976804-977031 [Pectobacterium carotovorum]
ATGCGTATTGTTTCGGTTTTTAAAAACGGTAATAACCGTGCCATTCGCTTGCCACGTGATATGGACTTTGAAGGGGTCAA
CGAACTGGAGATTGTGCGTGAGGGAGATACCATCATGCTGCGTCCGGTCAAACCCAATTGGCATTCGTTTTTGCAAGAAG
AGCGCGCTGACGCTGACTTTATGACAGAACGCCAGGATGTGGTCGAAGAGGGGAGATTCGAACTGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6