Detailed information of TA system TA152390

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 580010..580268
• Replicon: chromosome
• Accession: NZ_CP050240
• Organism: Erwinia amylovora strain FB-20

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: EGZ89_RS02515
• Protein ID: WP_004160031.1
• Coordinates: 580110..580268 (+)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	580010..580056 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EGZ89_RS02475	575456..575599	-	144	WP_004160049.1	hypothetical protein	-
EGZ89_RS02480	576072..576464	-	393	WP_004160048.1	DoxX family protein	-
EGZ89_RS02485	576674..576955	-	282	WP_004160039.1	YqjK-like family protein	-
EGZ89_RS02490	576955..577347	-	393	WP_004160038.1	phage holin family protein	-
EGZ89_RS02495	577349..577654	-	306	WP_004160037.1	DUF883 family protein	-
EGZ89_RS02500	577697..578068	-	372	WP_004160036.1	DUF1090 domain-containing protein	-
EGZ89_RS02505	578236..578628	-	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
EGZ89_RS02510	578625..579299	-	675	WP_004160034.1	DedA family protein	-
-	580010..580056	-	47	-	-	Antitoxin
EGZ89_RS02515	580110..580268	+	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
EGZ89_RS02520	580412..581644	-	1233	WP_004160030.1	serine/threonine transporter SstT	-
EGZ89_RS02525	581879..582859	-	981	WP_013035818.1	TerC family protein	-
EGZ89_RS02530	583272..584963	+	1692	WP_004160025.1	chloride channel protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T152390 WP_004160031.1 NZ_CP050240:580110-580268 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T152390 NZ_CP066143:c4132963-4132616 [Klebsiella pneumoniae U-0608239]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Nucleotide

• Length: 47 bp

>AT152390 NZ_CP050240:c580056-580010 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin