Detailed information of TA system TA152387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 34551..35122
• Replicon: plasmid pAsmA
• Accession: NZ_CP050188
• Organism: Aeromonas salmonicida subsp. masoucida strain RZ6S-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G9457_RS22945
• Protein ID: WP_219934990.1
• Coordinates: 34811..35122 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q07XG1
• Locus tag: G9457_RS22940
• Protein ID: WP_011638898.1
• Coordinates: 34551..34811 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G9457_RS22905 (G9457_22970)	30464..30730	-	267	WP_000699996.1	flagellar transcriptional regulator FlhD	-
G9457_RS22910 (G9457_22975)	30779..31492	-	714	WP_050886232.1	GNAT family protein	-
G9457_RS22915 (G9457_22980)	32175..32572	-	398	Protein_29	type II toxin-antitoxin system VapC family toxin	-
G9457_RS22920 (G9457_22985)	32569..32790	-	222	WP_050886233.1	type II toxin-antitoxin system VapB family antitoxin	-
G9457_RS22925 (G9457_22990)	32872..33198	+	327	WP_225990749.1	hypothetical protein	-
G9457_RS22930 (G9457_22995)	33235..33938	+	704	Protein_32	IS6-like element IS26 family transposase	-
G9457_RS22935 (G9457_23000)	33992..34381	-	390	Protein_33	recombinase family protein	-
G9457_RS22940 (G9457_23005)	34551..34811	+	261	WP_011638898.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G9457_RS22945 (G9457_23010)	34811..35122	+	312	WP_219934990.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G9457_RS22950 (G9457_23015)	35146..38232	+	3087	WP_219934991.1	Tn3 family transposase	-
G9457_RS22955 (G9457_23020)	38262..39137	+	876	WP_181317832.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	floR / formA / tet(A) / aac(6')-Ib-cr / blaOXA-1 / catB3 / catA2 / ARR-3 / qacE / sul1	-	1..252699	252699

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11794.62 Da
• Isoelectric Point: 8.5197

>T152387 WP_219934990.1 NZ_CP050188:34811-35122 [Aeromonas salmonicida subsp. masoucida]
MPVTYHLTPDAQSDLIGINRFTLAQWGTTQSKTYLSGLRQTIPLLAETPSLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Nucleotide

• Length: 312 bp

>T152387 NZ_CP066143:1886010-1887332 [Klebsiella pneumoniae U-0608239]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGCGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9330.74 Da
• Isoelectric Point: 6.4546

>AT152387 WP_011638898.1 NZ_CP050188:34551-34811 [Aeromonas salmonicida subsp. masoucida]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Nucleotide

• Length: 261 bp

>AT152387 NZ_CP066143:1885744-1886010 [Klebsiella pneumoniae U-0608239]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2K8ZVH1