Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 485170..486122 Replicon chromosome
Accession NZ_CP050178
Organism Rhodococcus pyridinivorans strain YC-JH2

Toxin (Protein)


Gene name pezT Uniprot ID H0JT30
Locus tag HBA53_RS02375 Protein ID WP_006552790.1
Coordinates 485553..486122 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID H0JT29
Locus tag HBA53_RS02370 Protein ID WP_006552789.1
Coordinates 485170..485556 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBA53_RS02345 (HBA53_02335) 480825..481757 + 933 WP_217579754.1 TAXI family TRAP transporter solute-binding subunit -
HBA53_RS02350 (HBA53_02340) 482082..482303 + 222 WP_217579755.1 hypothetical protein -
HBA53_RS02355 (HBA53_02345) 482896..483441 + 546 WP_217579756.1 hypothetical protein -
HBA53_RS02360 (HBA53_02350) 483458..483823 - 366 WP_217579757.1 HNH endonuclease -
HBA53_RS02365 (HBA53_02355) 483893..484963 - 1071 WP_019289578.1 methyltransferase domain-containing protein -
HBA53_RS02370 (HBA53_02360) 485170..485556 + 387 WP_006552789.1 hypothetical protein Antitoxin
HBA53_RS02375 (HBA53_02365) 485553..486122 + 570 WP_006552790.1 zeta toxin family protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-79)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20552.71 Da        Isoelectric Point: 10.6895

>T152381 WP_006552790.1 NZ_CP050178:485553-486122 [Rhodococcus pyridinivorans]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Download         Length: 570 bp

>T152381 NZ_CP066140:2153289-2153633 [Morganella morganii]
GTGTGGACAGTATTATTAACGGATTATTTTAATGAATGGTTGTCAAAACAAGATACCCGGATGAAAGAAAAAGTGCTCGC
ATCTCTTGGCAATCTTGAAATTTATGGCCCTGTTCTGACAAGACCTTATGTTGATACAGTTAAAACTTCTCAGTACCCGA
ATATGAAAGAATTGAGAATTTGGCATGCTGGTCGTGCAATACGTGCATTTTTTGCCTTTGATCCTGAAAGGCAGGCCATT
ATTTTATGTGCCGGAGATAAAGGGAAGGATAAACGATTTTATCAGACGATGATTCGTATTGCGGACGAACAATTTTCCTC
ATATCTTTCAGCAACGCAGGAATAA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14024.46 Da        Isoelectric Point: 4.5925

>AT152381 WP_006552789.1 NZ_CP050178:485170-485556 [Rhodococcus pyridinivorans]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYAEILAARGVTTVVLDDEGRLVEQRPDGSRQVLDDA

Download         Length: 387 bp

>AT152381 NZ_CP066140:2153638-2153937 [Morganella morganii]
ATGAAAACATTACAGGAAGTGATAGCGGCTCAATCACCGGAGAGCCGTGAGCGGATAAAACAACTGACTGATGAGCTGGT
TCTTGAAACCGGACTGCAACTTCTCAGAGAAGAACTTCATATCTCTCAGAAAACGCTGGCAAATAATCTTGGTATATCAC
AGCCGGCTGTTACTCAGATTGAGCAGCGCGGTAATGATATCAAACTGGCAACGCTGAAACGCTATATTGAGGCAATGGGC
GGAACACTTCGTCTGACGATTGAACTACCGACCGGTGATAACCGGATTTTTCGTGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T7RLW6

Antitoxin

Source ID Structure
AlphaFold DB H0JT29

References