Detailed information of TA system TA152345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1131392..1132048
• Replicon: chromosome
• Accession: NZ_CP050171
• Organism: Serratia fonticola strain CPSE11

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HAP32_RS05280
• Protein ID: WP_166733134.1
• Coordinates: 1131392..1131781 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: U2NVJ4
• Locus tag: HAP32_RS05285
• Protein ID: WP_021178792.1
• Coordinates: 1131785..1132048 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HAP32_RS05265	1128777..1129292	+	516	WP_166733132.1	MFS transporter	-
HAP32_RS05270	1129289..1130659	+	1371	WP_166733133.1	two-component system sensor histidine kinase BaeS	-
HAP32_RS05275	1130672..1131388	+	717	WP_021807142.1	two-component system response regulator BaeR	-
HAP32_RS05280	1131392..1131781	-	390	WP_166733134.1	type II toxin-antitoxin system VapC family toxin	Toxin
HAP32_RS05285	1131785..1132048	-	264	WP_021178792.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HAP32_RS05290	1132396..1132734	+	339	WP_021178793.1	YegP family protein	-
HAP32_RS05295	1132915..1134267	+	1353	WP_059201494.1	tRNA 5-hydroxyuridine modification protein YegQ	-
HAP32_RS05300	1134804..1135703	+	900	WP_166733135.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14191.43 Da
• Isoelectric Point: 7.2417

>T152345 WP_166733134.1 NZ_CP050171:c1131781-1131392 [Serratia fonticola]
MYMFDTNTVSQLFRQHPRLLAAMGRVPPSSVCISSITQAELLYGVAKRQNKALKQTVMMFLDAVTVYSWDSAAAHCYGVM
RASMEKQGSPMGALDQLIAAHAVSRGATIVTSDRAFTMVAELEVEDWTL

Nucleotide

• Length: 390 bp

>T152345 NZ_CP066125:c1491074-1490676 [Aeromonas veronii]
ATGGATATCATCCAGTTTCCTCCCGCTCGGGTGCTGGAGATTAACCACTACATCCTAGGTGCGTCGCCTGGTCACCAGGG
GCCTGCCAGCATAGCGTTATTGGAGGGGGCGCTTGGCCGCATCGACAACGCCATCGCCTACAACGGGCTAAATGATGTGT
TTCTCATCGCCGCAAAGTACGCAATGGCCATCGGTACCGCTCACGCCTTTTCCGATGCCAATAAGCGCACCGGACTTGCG
GTCTGCCTTGAGTATCTCTCCCTCAACGACTTCGAGATTGAAAGAGATAACGAGAAGCTGGCGGACGCTATGGTTGACCT
TGTGCTTGGCGAGCTGCCAGAAGAGTGGTTTGCCGATATCCTTTACGCGCTTTGGTTGGAAGAGCAAAAAACCTCCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10157.53 Da
• Isoelectric Point: 4.8232

>AT152345 WP_021178792.1 NZ_CP050171:c1132048-1131785 [Serratia fonticola]
MERVAKLFKNGRNQAVRLPVEFEFDVDQVYIRRDEQGNVILSKHPMKLDSWQPLLTMLQNVAVPADFLTADDRQQGVAER
DPFKEEQ

Nucleotide

• Length: 264 bp

>AT152345 NZ_CP066125:c1491253-1491074 [Aeromonas veronii]
ATGAAAGACAACTCCGTCAGCAACAAGTATGGATTGCCACAAGTGCAGAATCGGCCGCAAATCAAGGCTGAAAAGAACCT
GTGCCTGAACGGTGAAGAGGGCCGCCAGATCATCAAGTCTGAGACCAAGCTGACACTGAAGACCCACGAGAAGACCTTCA
CCCGTTTGGCTGATATGTAA

Structures

Antitoxin

• AlphaFold DB: U2NVJ4