Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2354497..2355127 Replicon chromosome
Accession NZ_CP050120
Organism Deinococcus radiodurans strain BND-54

Toxin (Protein)


Gene name mazF Uniprot ID Q9RX98
Locus tag HAV35_RS11855 Protein ID WP_010887062.1
Coordinates 2354774..2355127 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HAV35_RS11850 Protein ID WP_162177573.1
Coordinates 2354497..2354721 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HAV35_RS11825 2349987..2350166 + 180 WP_028328008.1 hypothetical protein -
HAV35_RS11830 2350287..2351062 + 776 Protein_2310 methyltransferase domain-containing protein -
HAV35_RS11835 2351218..2351442 + 225 WP_162177572.1 hypothetical protein -
HAV35_RS11840 2351623..2354090 - 2468 Protein_2312 ATP-dependent helicase HrpB -
HAV35_RS11845 2354087..2354500 - 414 WP_010887064.1 type II toxin-antitoxin system VapC family toxin -
HAV35_RS11850 2354497..2354721 - 225 WP_162177573.1 hypothetical protein Antitoxin
HAV35_RS11855 2354774..2355127 - 354 WP_010887062.1 endoribonuclease MazF Toxin
HAV35_RS11860 2355121..2355363 - 243 WP_010887061.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
HAV35_RS11865 2355542..2357023 + 1482 Protein_2317 carboxylesterase/lipase family protein -
HAV35_RS11870 2357071..2357700 - 630 WP_027479568.1 HAD family hydrolase -
HAV35_RS11875 2357702..2357881 - 180 WP_034349506.1 hypothetical protein -
HAV35_RS11880 2357904..2358866 - 963 WP_034349507.1 NAD(P)/FAD-dependent oxidoreductase -
HAV35_RS11885 2358887..2359570 - 684 WP_010887056.1 SDR family oxidoreductase -
HAV35_RS11890 2359567..2359938 - 372 Protein_2322 inorganic pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12450.24 Da        Isoelectric Point: 7.3219

>T152273 WP_010887062.1 NZ_CP050120:c2355127-2354774 [Deinococcus radiodurans]
MVSDYVPDAGHLVWLNFTPQAGHEQGGRRPALVLSPAAYNGVTGLMQACPVTSRAKGYPFEVTLPAHLGVSGVVLADHCR
SLDWRSRRAEQLAEAPADVLAEVRGKLGSLLGMSEKA

Download         Length: 354 bp

>T152273 NZ_CP066089:c998588-998283 [Citrobacter koseri]
ATGCCAAAGAAACTTGTCAGTATTGAAGACTTCCGTGACCAGTGGCTGGATGATTTTTTTATGTACTCTGCACCACATAA
GAAAATTCCCCCGGATATACATTCAGCATTGGCCCGTAAGCTCGATATCATAAACGCGGCAGTTAGCTACAAGGATTTGA
AGTCACCGCCGGGTAACAGATACGAAGAACTGGAAGGTAAATTGCAGGAATATTCTTCGATAAGAGTTAACAAGCAATAT
CGTTTGATATTCAAATGGGTGAACGGCAAGGCACAAGACCTCTACCTTGATCCACATGAGTATTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8229.23 Da        Isoelectric Point: 4.3481

>AT152273 WP_162177573.1 NZ_CP050120:c2354721-2354497 [Deinococcus radiodurans]
MTTLEARIENGKVVLTPEQAAELGLREGEVLPVTIAPHEAETEGNPFTRWIGTLPPLPDGEESARFYRRLRDGE

Download         Length: 225 bp

>AT152273 NZ_CP066089:c998195-997854 [Citrobacter koseri]
ATGAACCAGGCAACCAGAAAACCCACGACAGTTGGTGATATCCTTCTGTATGAATACCTGGAACCGCTTGACCTCAAAAT
TAATGATCTCGCGGAAATGTTGCAGGTGCATCGTAATACCGCCAGCGCATTGGTTAACAACAATCGTAAACTCACGACTG
ACATGGCTTTTCGCCTGTCTAAAGTTTTCGATACCTCTGTAGAGTTCTGGATGAACCTGCAAACTGCTGTAGATGTATGG
GAAACTGAAAACAATGCCCGCCTTCAGGTAGAGATGAGCAGGGTGATTACGGCGAGCGATTTTCTTGCGGAACGTCAGAA
ACAAGAAAAGAAAGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7D2M
PDB 7D2P
PDB 7DHP
PDB 7D2Q
PDB 7D28
PDB 7D2N

Antitoxin

Source ID Structure

References