Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1787194..1787784 Replicon chromosome
Accession NZ_CP050078
Organism Citrobacter koseri strain NJ

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NCK_RS08405 Protein ID WP_047462842.1
Coordinates 1787452..1787784 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag NCK_RS08400 Protein ID WP_047462840.1
Coordinates 1787194..1787451 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NCK_RS08390 (1786348) 1786348..1786815 + 468 Protein_1643 hypothetical protein -
NCK_RS08395 (1786893) 1786893..1787096 - 204 WP_072025325.1 hypothetical protein -
NCK_RS08400 (1787194) 1787194..1787451 + 258 WP_047462840.1 antitoxin Antitoxin
NCK_RS08405 (1787452) 1787452..1787784 + 333 WP_047462842.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NCK_RS08415 (1788265) 1788265..1789182 + 918 WP_047462844.1 nitrogen assimilation transcriptional regulator NAC -
NCK_RS08420 (1789284) 1789284..1790234 + 951 WP_219936885.1 HTH-type transcriptional regulator Cbl -
NCK_RS08430 (1790448) 1790448..1791245 - 798 WP_012131863.1 DgsA anti-repressor MtfA -
NCK_RS08440 (1792038) 1792038..1792646 + 609 WP_047462847.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11772.63 Da        Isoelectric Point: 10.5834

>T152211 WP_047462842.1 NZ_CP050078:1787452-1787784 [Citrobacter koseri]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARAAGFTVSLDGTGTKTTGVIRCDQPRTI
DMGARSGKRLERIPDAVVNEVLARLEAIMS

Download         Length: 333 bp

>T152211 NZ_CP066042:c1391178-1390990 [Staphylococcus saccharolyticus]
ATGAGTTTACATTTTTATATCCTATTATGGCTTGCCATACTGTTTATTATTGCAGGAACTATCTTATTAATTACAATGCT
AAAAACTAAAAAAGAAGAAAGAAAAGAATCCTACTTAGGCTTTACAGTCATCTTCTTAATCTTTGGTATTGCCATACTTA
TCTACACGCTTATATTTGGAATTTTGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9441.97 Da        Isoelectric Point: 4.6127

>AT152211 WP_047462840.1 NZ_CP050078:1787194-1787451 [Citrobacter koseri]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDRKWIDAPAV
GKELL

Download         Length: 258 bp

>AT152211 NZ_CP066042:c1391466-1391209 [Staphylococcus saccharolyticus]
ATGAAACTAATTAGAATAAATGTAATTAACGTGATATTAACTATACTATTTATGGCTTTTAACGTACTCATTACCTACAA
CGAGAATATTGATAACAATTTGTGGTTAGTACCAGGATTAATCATTTGTGGTATTACTTTACTTACAAGTTTAACAATAG
CTATTGTGTATACTGATTTATTTAGTGAAATTTTATTTTTTATCAATATCATTTTAGCACTATATTATATCTATCCTATT
CTTTATGAGTTCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References